Results 81 to 90 of about 52,768,713 (299)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Multivariate trend comparisons between autocorrelated climate series with general trend regressors [PDF]
Inference regarding trends in climatic data series, including comparisons across different data sets as well as univariate trend significance tests, is complicated by the presence of serial correlation and step-changes in the mean.
Timothy Vogelsang, Ross McKitrick
core
Comment on: Trends in research related to high myopia from 2010 to 2019: a bibliometric and knowledge mapping analysis [PDF]
International Journal of Ophthalmology, 2022 Yuh-Shan Ho
doaj +1 more source
Global trends in tertiary lymphoid structures: a bibliometric analysis from 2014 to 2023
Frontiers in ImmunologyAim and backgroundTertiary lymphoid structures (TLS) are increasingly recognized for their role in immunity. Despite growing interest, a systematic bibliometric analysis of TLS-related research has been lacking.
Yiwen Bao +14 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
The impact of Covid-19 on health research charities
, 2021 HRCI conducted a survey of its members in December 2020 to ascertain the impact of Covid-19 on Irish Health Research Charities.
Health Research Charities Ireland, /
core
Comment on: Bibliometric analysis of glaucoma-related literature based on SCIE database: a 10-year literature analysis from 2009 to 2018 [PDF]
International Journal of Ophthalmology, 2023 Yuh-Shan Ho
doaj +1 more source
ElectrochemistryThe Center for Advanced Battery Collaboration (ABC) was established at the National Institute for Materials Science with the support of COI-NEXT, Japan Science and Technology Agency (JST).
Kei NISHIKAWA +11 more
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source