Results 141 to 150 of about 52,768,713 (299)
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Measuring trend output: how useful are the Great Ratios? [PDF]
Standard macroeconomic models suggest that the 'great ratios' of consumption to output and investment to output should be stationary. The joint behaviour of consumption, investment and output can then be used to measure trend output.
Cliff L.F. Attfield +1 more
core
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Neurodegenerative diseases are characterised by synaptic loss and cognitive decline but are also typified by debilitating systemic comorbidities such as high prevalence of bone fracture.
Trend, Jacob
core +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Empower, innovate, transform: driving the future of health research. 10th anniversary of the Irish Health Research Forum. Recommendations and Event Report [PDF]
This landmark event for the Irish Health Research Forum offered an opportunity to reflect on the key issues addressed by past Forum events and, in particular, to identify the recurring themes that have emerged from the recommendations generated from ...
Health Research Charities Ireland
core +1 more source
Unraveling the research trend of ecological civilization and sustainable development: A bibliometric analysis. [PDF]
Ambio, 2023 Zhao W, Zhou A, Yin C.
europepmc +1 more source