Results 121 to 130 of about 98,311 (259)

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Exploring utilisation of knee and hip osteoarthritis healthcare services and its predictors: a scoping review. [PDF]

BMJ Open
Neumann S, Weber F, Grüneberg C, Schenk L, Thiel C, Gellert P, Peschke D.   +6 more
europepmc   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Mapping healthcare service utilisation for diabetes and hypertension in Tanzania mainland: bayesian spatial modeling. [PDF]

Front Health Serv
Magwaja E, Todd J, Chang'a L, Kapesa A, Musenge E, PrayGod G, Kitilya B, Kamala E, Kapyolo E, Faurholt-Jepsen D, Matsena Zingoni Z.   +10 more
europepmc   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Postnatal Care Utilisation Among Adolescent Mothers in India: A Pooled Cross-Sectional Study of NFHS-4 and NFHS-5. [PDF]

Public Health Chall
Singh A, Singh A, Chandra R, Hossain M, Jain U.   +4 more
europepmc   +1 more source

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source

Exploring global access to healthcare and utilisation for neurocutaneous syndromes: a scoping review protocol. [PDF]

BMJ Open
Kebede B, Molla A, Alemayehu B.
europepmc   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Landscape of national antibiotic utilisation in Malaysia: an analysis of national pharmaceutical sales data from 2019 to 2023. [PDF]

J Pharm Policy Pract
Lim AH, Ab Rahman N, Nasarudin SNS, Mohamad Yahaya AH, Kamal M, Mohd Shah MS, Awang NH, Sim BLH, Chidambaram SK, Sivasampu S, Tok PSK.   +10 more
europepmc   +1 more source