Results 131 to 140 of about 98,311 (259)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Maternal health, service utilisation and its determinants among women who gave birth in the last 12 months across Afar, Benishangul-Gumuz, Gambella and Somali region, Ethiopia: a cross-sectional study in four developing regional states of Ethiopia. [PDF]

BMJ Open
Yadate T, Abute L, Alemu S, Dida N, Geleta T, Sharma R, Mon HS, Abebe F, Addisu H, Abebe Y, Dejene T.   +10 more
europepmc   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Healthcare Utilisation in Ageing Adults With Intellectual Disability: Longitudinal Evidence From Five Waves of IDS-TILDA. [PDF]

J Appl Res Intellect Disabil
McMahon M, Paul A, Ryan C, Lynch L, McCallion P, McCarron M, Burke E.   +6 more
europepmc   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

A cross-sectional survey of men's attitudes towards public health services and their utilisation practices in Limpopo Province, South Africa. [PDF]

S Afr Fam Pract (2004)
Chavalala L, Makhado L, Lebese RT.
europepmc   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Barriers and facilitators to service utilisation and management of sexually transmitted infections in India: a multicentric mixed-method approach study protocol. [PDF]

BMJ Open
Aggarwal S, Khandekar J, Banerjee B, Agarwal P, Paul S, Parashar M, Goel AD, Lakshmi PVM, Datkhile K, Naik BN, Goel M, Verma V, Rajan S, Das C, Nigam K.   +14 more
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Pre-pandemic and pandemic healthcare utilisation among children with intellectual disabilities compared to the general population: a register study (IDcare). [PDF]

BMJ Paediatr Open
Axmon A, Sandberg M.
europepmc   +1 more source