Results 101 to 110 of about 1,823,507 (396)

MCM8-9 complex promotes resection of double-strand break ends by MRE11-RAD50-NBS1 complex. [PDF]

, 2015
MCM8-9 complex is required for homologous recombination (HR)-mediated repair of double-strand breaks (DSBs). Here we report that MCM8-9 is required for DNA resection by MRN (MRE11-RAD50-NBS1) at DSBs to generate ssDNA.
Dutta, Anindya, Handa, Naofumi, Im, Jun-Sub, Kowalczykowski, Stephen C, Lee, Kyung Yong, Park, Jonghoon, Shibata, Etsuko   +6 more
core   +1 more source

Preoperative/Neoadjuvant Therapy in Pancreatic Cancer: A Systematic Review and Meta-analysis of Response and Resection Percentages

PLoS Medicine, 2010
Jörg Kleef and colleagues systematically reviewed studies on neoadjuvant therapy and tumor response, toxicity, resection, and survival percentages in pancreatic cancer and suggest that patients with locally nonresectable tumors should be included in ...
S. Gillen, T. Schuster, C. Meyer zum Büschenfelde, H. Friess, J. Kleeff   +4 more
semanticscholar   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Complete mesocolic excision does not increase short-term complications in laparoscopic left-sided colectomies : a comparative retrospective single-center study [PDF]

, 2019
Background: Since the implementation of total mesorectal excision (TME) in rectal cancer surgery, oncological outcomes improved dramatically. With the technique of complete mesocolic excision (CME) with central vascular ligation (CVL), the same surgical ...
Claeys, Donald, Defoort, Barbara, Dewulf, Maxime, Kalmar, Alain, Muysoms, Filip, Pletinckx, Pieter, Vandenberk, Bert   +6 more
core   +2 more sources

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Usefulness of Autofluorescence Imaging for Estimating the Extent of Gastric Neoplastic Lesions: A Prospective Multicenter Study

Gut and Liver, 2008
Background/Aims: The aim of this study was to determine whether the margin of early to be detected gastric cancer (EGC) and gastric adenoma is easier to be detected with autofluorescence imaging (AFI) than with white-light endoscopy (WLE).
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

The Art of Intraoperative Glioma Identification

Frontiers in Oncology, 2015
A major dilemma in brain tumor surgery is the identification of tumor boundaries to maximize tumor excision and minimize postoperative neurological damage.
Zoe Z Zhang, Lisa B.E. Shields, David eSun, Yi Ping eZhang, Matthew A Hunt, Christopher Brian Shields, Christopher Brian Shields   +6 more
doaj   +1 more source

Comorbid Medical Conditions as Predictors of Overall Survival in Glioblastoma Patients [PDF]

, 2019
Glioblastoma (GBM) is an aggressive central nervous system tumor with a poor prognosis. This study was conducted to determine any comorbid medical conditions that are associated with survival in GBM.
Broaddus, William C., Carr, Matthew T., Dincer, Alper, Hochheimer, Camille J., Opalak, Charles F., Poulos, Nora, Ravindra, Lakshmi, Rock, Andrew K., Sima, Adam P., Zhang, Fan Lily   +9 more
core   +1 more source

Impact of MAFLD on HBV-Related Stage 0/A Hepatocellular Carcinoma after Curative Resection [PDF]

, 2021
Yen‐Po Lin, Shu-Hsien Lin, Chih‐Chi Wang, Chih‐Che Lin, Ding-Wei Chen, Ching‐Hui Chuang, Pao‐Yuan Huang, Chao‐Hung Hung, Shih-Yu Yang, Wei-Ru Cho, Yu-Syuan Chen, Ming‐Chao Tsai   +11 more
openalex   +1 more source