Results 101 to 110 of about 1,106,310 (293)

Physical Function and Quality of Life After Resection of Mobile Spine Chondrosarcoma. [PDF]

, 2019
Study Design:Retrospective cohort study. Objectives:(1) To assess patient-reported outcomes-physical function, pain, and quality of life-in patients who underwent resection of a mobile spine chondrosarcoma.
Chen, Yen-Lin E, DeLaney, Thomas F, Hartveldt, Stefan, Hornicek, Francis J, Janssen, Stein J, Paulino Pereira, Nuno Rui, Schwab, Joseph H, Stoop, Nicky   +7 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Accuracy of computerized tomography in determining hepatic tumor size in patients receiving liver transplantation or resection [PDF]

, 1984
Computerized tomography (CT) of liver is used in oncologic practice for staging tumors, evaluating response to treatment, and screening patients for hepatic resection.
Bron, K, Dekker, A, Iwatsuki, S, Kowal, C, Mittal, R, Schade, R, Starzl, T, Straub, W, Van Thiel, D   +8 more
core   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Physical Activity and Quality of Life After Distal Femur Tumor Resection and Limb Salvage

Journal of Functional Morphology and Kinesiology
Background/Objectives: Distal femur tumor resection with limb salvage is a demanding procedure that offers hope for patients by preserving the limb rather than opting for amputation. While limb salvage can improve both physical function and psychological
Dimitra C. Galanis, Ioannis Zafeiris, Fotini M. Soukakou, Dimitra P. Papagelopoulos, Panayiotis Gavriil, Ioannis G. Trikoupis, Olga D. Savvidou, Konstantinos Vlasis, Vasileios A. Kontogeorgakos, Panayiotis J. Papagelopoulos   +9 more
doaj   +1 more source

Acinar cell carcinoma: a rare pancreatic malignancy

Clinics and Practice, 2013
Acinar cell carcinoma of the pancreas is a rare pancreatic malignancy, constituting only 1-2% of all the pancreatic tumors. A young adult male presented with chronic diarrhea and upper abdominal pain, on investigations was found to have a large ...
Poras Chaudhary, Gyan Ranjan, Anil Chaudhary, Alok Kumar Tiwari, Mohinder P. Arora   +4 more
doaj   +1 more source

Imaging memory in temporal lobe epilepsy: predicting the effects of temporal lobe resection [PDF]

, 2010
Functional magnetic resonance imaging can demonstrate the functional anatomy of cognitive processes. In patients with refractory temporal lobe epilepsy, evaluation of preoperative verbal and visual memory function is important as anterior temporal lobe ...
Bonelli, S. B., Duncan, J. S., Koepp, M. J., Powell, R. H. W., Samson, R. S., Symms, M. R., Thompson, P. J., Yogarajah, M.   +7 more
core  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Principles of Pituitary Surgery [PDF]

, 2018
Key Points 1. Understand the principles of pituitary surgery including the key-elements of surgical planning and decision-making 2. Identify the technical nuances distinguishing the endoscopic from the microscopic transsphenoidal approach 3.
Evans, James J., Farag, MD, Alexander, Farrell, MD, Christopher J, Nyquist, MD, Gurston G., Rosen, Marc, MD   +4 more
core   +2 more sources

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source