Results 131 to 140 of about 1,823,507 (396)

Amide‐Linked Local Anesthetics Alter Tumor Biology in a Complex Human Tissue Model of Non‐Small Cell Lung Adenocarcinoma

Advanced Biology, EarlyView.
Amide local anesthetics (LA) affect tumor burden in various preclinical studies, possibly via their anti‐inflammatory properties. However, a translation into clinical evidence is still lacking. The current study demonstrates that LA ‐ even at clinically relevant concentrations – exert a strong anti‐tumoral effect in a complex ex vivo model patient ...
Juliane Krömer, Sebastian Krämer, Ngoc Anh Hoang, Doreen Sittig, Isabella Metelmann, Uta‐Carolin Pietsch, Sebastian N. Stehr, Sonja Kallendrusch, Tobias Piegeler   +8 more
wiley   +1 more source

Does the revised cardiac risk index predict cardiac complications following elective lung resection? [PDF]

, 2013
Background: Revised Cardiac Risk Index (RCRI) score and Thoracic Revised Cardiac Risk Index (ThRCRI) score were developed to predict the risks of postoperative major cardiac complications in generic surgical population and thoracic surgery respectively.
A Bobbio, A Brunelli, A Brunelli, A Brunelli, Amy Kerr, Andrea Marshall, AS Detsky, Babu Naidu, CA Polanczyk, CD Parmar, D Amar, DJ Bertges, DW Hosmer, E Lim, Ehab Bishay, HC Fernando, JP Mathew, L Goldman, LA Fleisher, Maninder Kalkat, MK Ferguson, MK Ford, Pala Rajesh, Richard Steyn, Robin Wotton, TH Lee, V Fuster, WD Neary   +27 more
core   +2 more sources

Evaluating the Predictive Value of Glioma Growth Models for Low-Grade Glioma After Tumor Resection [PDF]

, 2023
Karin A. van Garderen, Sebastian R. van der Voort, Maarten M.J. Wijnenga, Fatih Incekara, Ahmad Alafandi, Georgios Kapsas, Renske Gahrmann, Joost W. Schouten, Hendrikus J. Dubbink, Arnaud J.P.E. Vincent, Martin J. van den Bent, Pim J. French, Marion Smits, Stefan Klein   +13 more
openalex   +1 more source

Primary Human Tissue Models for Metabolic Dysfunction‐Associated Liver Disease ‐ toward Streamlining Drug Discovery with Patient‐Derived Assays

Advanced Biology, EarlyView.
The review provides a critical up‐to‐date overview of the current landscape of human in vitro models for fatty liver disease, including spheroids, organoids, organ‐on‐a‐chip systems, bioprinted liver constructs and precision‐cut liver slices. Their utility for faithfully modeling different stages of MASLD and MASH are evaluated and their compatibility ...
Sonia Youhanna, Nayere Taebnia, Yingxin Liang, Ningtao Cheng, Yi Wang, Maurice Michel, Volker M. Lauschke   +6 more
wiley   +1 more source

DNA DSB repair pathway choice: an orchestrated handover mechanism [PDF]

, 2014
DNA double strand breaks (DSBs) are potential lethal lesions but can also lead to chromosome rearrangements, a step promoting carcinogenesis. DNA non-homologous end-joining (NHEJ) is the major DSB rejoining process and occurs in all cell cycle stages ...
A Kakarougkas, Friedberg EC, Haynes RH, Jeggo PA, P A Jeggo, Wilson JH   +5 more
core   +1 more source

Impact of sarcopenia on outcomes of patients undergoing liver resection for hepatocellular carcinoma

, 2022
Jinhuan Yang, Kaiwen Chen, Chongming Zheng, Kaiyu Chen, Jian Lin, Qishan Meng, Ziyan Chen, Liming Deng, Haitao Yu, Tuo Deng, Zhiyuan Bo, Qikuan He, Yi Wang, Gang Chen   +13 more
openalex   +1 more source

EXO1 resection at G-quadruplex structures facilitates resolution and replication [PDF]

, 2020
Susanna Stroik, Kevin Kurtz, Kevin Lin, Sergey Karachenets, Chad L. Myers, Anja‐Katrin Bielinsky, Eric A. Hendrickson   +6 more
openalex   +1 more source

A randomised trial of endoscopic submucosal dissection versus endoscopic mucosal resection for early Barrett’s neoplasia

Gut, 2016
Background For endoscopic resection of early GI neoplasia, endoscopic submucosal dissection (ESD) achieves higher rates of complete resection (R0) than endoscopic mucosal resection (EMR).
G. Terheggen, Eva Maria Horn, M. Vieth, H. Gabbert, M. Enderle, Alexander Neugebauer, B. Schumacher, H. Neuhaus   +7 more
semanticscholar   +1 more source

Pelvic Resections

Orthopedics, 2012
The complexity of pelvic anatomy and the extent of tumor growth makes treatment of patients with primary bone sarcomas in the pelvis difficult in terms of local control. Before the 1970s, most tumors in the bony pelvis were surgically treated with hindquarter amputation.
Mavrogenis AF, Soultanis K, Patapis P, Guerra G, Fabbri N, RUGGIERI, PIETRO, Papagelopoulos P.J.   +6 more
openaire   +4 more sources

FOXP3 Polymorphism and Upregulation of the CXCL12‐CXCR4‐SNAIL Axis with High Infiltration of M2TAM by STAT3/NFKB Pathways Influence the Survival of Cervical Cancer Patients

Advanced Biology, EarlyView.
This study highlights how cervical carcinoma progression is shaped by immune–tumor interactions within the TME. M2‐TAM infiltration, regulated through STAT3/NF‐κB and linked to CXCL12–CXCR4, promotes immune suppression, angiogenesis, and poor survival.
George A. Lira, Fábio M. de Azevedo, Ingrid G. S. Lins, Janaína C. O. Crispim, Giovanna A. Lira, Rômulo S. Cavalcante, Ricardo Cobucci, Carolina O. Mendes‐Aguiar, Rafaela Torres Dantas Da Silva, Vinícius E. da Silva, Ryan C. Q. Aquino, Raimundo F. Araújo Júnior   +11 more
wiley   +1 more source