Results 31 to 40 of about 848,850 (261)

Imaging memory in temporal lobe epilepsy: predicting the effects of temporal lobe resection [PDF]

, 2010
Functional magnetic resonance imaging can demonstrate the functional anatomy of cognitive processes. In patients with refractory temporal lobe epilepsy, evaluation of preoperative verbal and visual memory function is important as anterior temporal lobe ...
Thompson, P. J., Samson, R. S., Yogarajah, M., Symms, M. R., Koepp, M. J., Powell, R. H. W., Duncan, J. S., Bonelli, S. B.   +7 more
core  

Aggressive resection of frequent peritoneal recurrences in colorectal cancer contributes to long-term survival [PDF]

, 2016
2016-11We report a long-term survivor of colorectal cancer who underwent aggressive, frequent resection for peritoneal recurrences. A 58-year-old woman was diagnosed with descending colon cancer.
Hosoi, Takahiro, Tsutsuyama, Masayuki, Komori, Koji, Oshiro, Taihei, Ouchi, Akira, Tanaka, Hideharu, Kawakami, Jiro, Shimizu, Yasuhiro, Kinoshita, Takashi, Ito, Yuichi, Shigeyoshi, Itaru, Natsume, Seiji, Hayashi, Daisuke, Abe, Tetsuya, Uemura, Norihisa, Senda, Yoshiki, Misawa, Kazunari, Ito, Seiji, Akazawa, Tomoyuki   +18 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Venous thromboembolism following colorectal resection [PDF]

, 2016
AimThe study investigated the rate of significant venous thromboembolism (VTE) following colorectal resection during the index admission and over 1 year following discharge.

core   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Comparison of the prognostic value of tumour and patient related factors in patients undergoing potentially curative surgery for colon cancer [PDF]

, 2010
<b>Aim</b>: To comprehensively compare the prognostic value of tumour and patient-related factors in patients undergoing curative surgery for colon cancer.
Roxburgh, C.S.D., Guthrie, G., Wallace, A.M., McMillan, D.C., Horgan, P.G.   +4 more
core   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Defining Meyer's loop-temporal lobe resections, visual field deficits and diffusion tensor tractography [PDF]

, 2009
Anterior temporal lobe resection is often complicated by superior quadrantic visual field deficits (VFDs). In some cases this can be severe enough to prohibit driving, even if a patient is free of seizures.
M Yogarajah (16050209), J S Duncan (16050227), McEvoy, A.W., M J Koepp (13602235), Focke, N.K., Koepp, M. J., Duncan, John S., M R Symms (16042382), Koepp, Matthias J., Duncan, J.S., Symms, M.R., Alexander, D. C., Parker, G. J M, Acheson, J., Bonelli, S., A W McEvoy (16050224), S Bonelli (16050215), G J M Parker (16050218), Mara Cercignani (4463104), Alexander, Daniel C., Alexander, D.C., Koepp, M.J., McEvoy, A. W., Parker, G.J.M., J Acheson (10343627), Yogarajah, Mahinda, Symms, Mark R., Bonelli, Silvia B., Cercignani, M., D C Alexander (16050221), Yogarajah, M., Focke, N. K., Symms, M. R., Focke, Niels K., Duncan, J. S., N K Focke (16050212), Parker, G. J. M.   +36 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source