Results 151 to 160 of about 715,165 (308)

Reserve price effects in auctions: estimates from multiple RD designs [PDF]

We present evidence from 260,000 online auctions of second-hand cars to identify the impact of public reserve prices on auction outcomes. To establish causality, we exploit multiple discontinuities in the relationship between reserve prices and vehicle ...
Syngjoo Choi, Lars Nesheim, Imran Rasul
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Low Steatosis May Signal Failing Reserve in Cirrhosis due to Metabolic Dysfunction-Associated Steatotic Liver Disease. [PDF]

Liver Int
Li H.
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

[Plan of] Katzie Indian Reserve, Wanack Indian Reserve, Matzquee Indian Reserve A, Matzquee Indian Reserve B [original]

[No surveyor name or date; not signed by Superintendent of Indian Affairs.] Map showing several Reserves along the Fraser River including the Katzie Indian Reserve, Wanack [now Whonnock] Indian Reserve, Matzquee Indian Reserve A, Matzquee Indian Reserve
Surveyor General of British Columbia
core   +1 more source

Hyperopic reserve, early myopia risk and screening strategies in children: A multi-regional analysis from the CREAM-KIDS consortium. [PDF]

iScience
Pan W, Harrington S, Lingham G, Moore M, Foo LL, Kneepkens SCM, van Hemert DJ, Saunders K, McCullough S, Willams K, Pärssinen O, Baraas RC, Hagen LA, French A, Saw SM, Yam J, Klaver C, CREAM-KIDS Consortium, Flitcroft I, Lan W.   +19 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

What should we be measuring when we measure cognitive reserve? Distinguishing proxies, prediction, and mechanism. [PDF]

Front Psychol
Paap KR.
europepmc   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

As-If-Markov Reserves for Reserve-Dependent Payments

Insurance: Mathematics and Economics
Marcus C. Christiansen, Boualem Djehiche
openaire   +1 more source