Results 111 to 120 of about 845,239 (199)

Lymphoid and CXCR4 Cell Targeted Lipid Nanoparticles Facilitate HIV‐1 Proviral DNA Excision

Advanced Healthcare Materials, EarlyView.
Advancements in ART improve HIV‐1 patient outcomes but are unable to eliminate latent viral DNA. To address this, CXCR4‐targeted lipid nanoparticles (T‐LNPs) for delivering CRISPR‐Cas9 to excise HIV‐1 DNA in infected cells are developed. These T‐LNPs achieve ≈60% HIV‐1 DNA excision efficacy in blood and splenic tissue, demonstrating promise for ...
Sudipta Panja, Lubaba A. Zaman, Chen Zhang, Milankumar Patel, Santhi Gorantla, Prasanta K. Dash, Howard E. Gendelman   +6 more
wiley   +1 more source

Editorial: Deep neural network architectures and reservoir computing. [PDF]

Front Artif Intell
Nobukawa S, Bhattacharya AK, Hirose A.
europepmc   +1 more source

Synergistic Combination of Tamoxifen–Tetraphenylethylene Co‐Assembled Micelles and Orlistat‐Induced Lipid Droplet Inhibition to Overcome Tamoxifen Resistance

Advanced Healthcare Materials, EarlyView.
Molecule 2, which contains a shorter oligoether chain, binds to tamoxifen via structural similarity forming micelles with a positive surface charge, thereby enhancing cellular uptake. These fluorescent micelles induce lipid droplet (LD) accumulation, exhibit strong fluorescence, and effectively overcome tamoxifen resistance by synergizing with orlistat‐
Jung Yeon Park, Jeehee Lee, Young Yong Kim, Sanghee Lee, Yongju Kim   +4 more
wiley   +1 more source

The role of Tat in HIV latency and reactivation. [PDF]

Front Immunol
Margolis DM, Browne EP.
europepmc   +1 more source

An Innovative “Tooth‐On‐Chip” Microfluidic Device Emulating the Structure and Physiology of the Dental Pulp Tissue

Advanced Healthcare Materials, EarlyView.
This work presents a “tooth‐on‐chip” device that mimics dental pulp tissue. By co‐culturing key cell types, it recreates vascular networks, stem cell niches, the odontoblast/dentine interface, and trigeminal innervation. This innovative platform provides a unique model of dental pulp structure and physiology, with significant potential for accelerating
Alessandro Cordiale, Deborah Stanco, Roberta Visone, Bernd Stadlinger, Pierfrancesco Pagella, Marco Rasponi, Thimios A. Mitsiadis   +6 more
wiley   +1 more source

Multidisciplinary 3D geological-petrophysical reservoir characterization of Abu Sennan Field, Abu Gharadig Basin, Egypt. [PDF]

Sci Rep
Mamdouh M, Othman AAA, Mostafa T.
europepmc   +1 more source

HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation

Nature Network Boston, 2009
N. Chomont, M. El-Far, P. Ancuța, L. Trautmann, F. Procopio, B. Yassine-Diab, G. Boucher, M. Boulassel, G. Ghattas, J. Brenchley, T. Schacker, Brenna J. Hill, D. Douek, J. Routy, E. Haddad, R. Sékaly   +15 more
semanticscholar   +1 more source

Advanced Nanoparticle Therapeutics for Targeting Neutrophils in Inflammatory Diseases

Advanced Healthcare Materials, EarlyView.
This review highlights recent advances in nanoparticle‐based strategies to modulate neutrophil activity in inflammatory diseases. By targeting inflammatory neutrophils, NET formation, and neutrophil apoptosis or recruitment, these approaches aim to improve therapeutic precision.
Min Ji Byun, Elizabeth S. Nakasone, Ha Eun Shin, Hyojin Lee, Jong‐Chan Park, Wonhwa Lee, Wooram Park, Chun Gwon Park, Juwon Park, Se‐Na Kim   +9 more
wiley   +1 more source

The effect of left atrial reservoir strain on right ventricular dysfunction in left-sided heart failure. [PDF]

Quant Imaging Med Surg
Li G, Wang Y, Ma C.
europepmc   +1 more source

Robust pH Sensing Using a Graphene Oxide and Covalent Organic Frameworks Composite for Gastro‐esophageal Reflux Disease Diagnosis

Advanced Healthcare Materials, EarlyView.
A stable composite pH sensor is developed by coating graphene oxide (GO) nanosheets with covalent organic frameworks (COFs) to improve stability and sensitivity in acidic environments. The GO/COFs sensor demonstrates high selectivity, linearity, and biocompatibility, offering a promising strategy for continuous pH monitoring in gastro‐esophageal reflux
Ahmed H. M. Salem, Jianhui Zhang, Ashley Lam, Haowei Wang, Umber Cheema, Laurence B. Lovat, Manish K. Tiwari   +6 more
wiley   +1 more source