Results 121 to 130 of about 1,282,329 (297)

Dual‐Peptide Nanoplatform: Mesoporous Silica Nanoparticles Functionalized With a Cell‐Penetrating Peptide and Loaded With Rationally Designed Antimicrobial Peptides for Tuberculosis Therapy

Advanced Healthcare Materials, EarlyView.
Machine learning–guided engineering of a plectasin‐derived peptide yields DC05, a potent antimycobacterial candidate. Encapsulation into tuftsin‐functionalized mesoporous silica nanoparticles enhances intracellular delivery, stability, and activity against Mycobacterium tuberculosis while maintaining low cytotoxicity and minimal hemolysis. The combined
Christian S. Carnero Canales, Cesar Augusto Roque‐Borda, Ana Carolina Cerqueira Negri, Oswaldo Ramirez Delgado, Letícia Oliveira Catarin Nunes, Flávia Aparecida Resende, Hernane Barud, Norival Alves Santos‐Filho, Saulo Santesso Garrido, Karen Cristina Oliveira, Alexandra Ivo de Medeiros, Rafael Miguel Sábio, Fernando Rogério Pavan   +12 more
wiley   +1 more source

A simple model for Carnot heat engines

, 2008
We present a (random) mechanical model consisting of two lottery-like reservoirs at altitude $E_h$ and ...
Arnaud, Jacques, Chusseau, Laurent, Philippe, Fabrice   +2 more
core   +1 more source

No Room in the Reservoir

Minds and Machines
Abstract There is growing enthusiasm in some quarters for purging representation from the set of concepts necessary to understand intelligence, at least in some circumstances. But to date, the list of explicit alternatives remains thin, with few plausible examples of intelligent systems the operation of which can be clearly articulated in non-
openaire   +1 more source

Flash Assembloids: A Rapid Biofabrication of a Platform for Modeling Early Glioblastoma Invasion at the Glioblastoma–Brain Organoid Interfaces

Advanced Healthcare Materials, EarlyView.
This study presents a bioengineered assembloid (ASM) system combining glioblastoma (GBM) cells in oxidized alginate (OA) microgels with dorsal organoids (DOs). This model simulates brain tumor‐host interactions, revealing enhanced GBM invasion, altered gene expression, and aggressive infiltration patterns, demonstrating ASM as a valuable platform for ...
Chao Liang, Henry Robert Howard, Shihui Chen, Won‐Young Choi, Summer Cao, Arthur Chien, Kevin Zou, Michael Kassiou, Fabien Delerue, Ho Sang Jung, Yeonju Park, Young Mee Jung, Yong‐Dae Kwon, Karrie M. Kiang, Gilberto Ka‐Kit Leung, Ryohichi Sugimura, Ann‐Na Cho, Sang Jin Lee   +17 more
wiley   +1 more source

Unlocking thin sand potential: a data-driven approach to reservoir characterization and pore pressure mapping

Geomechanics and Geophysics for Geo-Energy and Geo-Resources
The gradual decline of production of the major fields of the Indus Basin has influenced the field pressure. Therefore, the prospects need to be assessed by the petro-elastic relationship.
Muhsan Ehsan, Rujun Chen, Umar Manzoor, Muyyassar Hussain, Kamal Abdelrahman, Zahid Ullah Khan, Jar Ullah, Muhammad Khizer Iftikhar, Farooq Arshad   +8 more
doaj   +1 more source

Development of a Synthetic Hydrogel to Foster Microvascularization of an Endometriosis Microphysiological System

Advanced Healthcare Materials, EarlyView.
ABSTRACT The ascent of novel alternative methods in drug development spotlights the dual needs for improved biological fidelity to in vivo, along with reproducibility, especially in regulatory applications. The need for pre‐clinical models of patient‐derived endometriosis lesions motivates the development of a vascularizable, completely synthetic ...
Lauren Pruett, Laura Bahlmann, Ryan Ogi, Angela Jiao, Priyatanu Roy, Matthew Johnson, David Trumper, Linda Griffith   +7 more
wiley   +1 more source

Aptamer‐Based Delivery Systems for VEGF and NGF Modulation in Ocular Therapies

Advanced Healthcare Materials, EarlyView.
Aptamer‐based delivery systems targeting NGF and VEGF hold significant potential for precise and sustained treatment of complex diseases affecting both the anterior and posterior segments of the eye. This review critically summarizes current strategies for NGF and VEGF delivery as well as VEGF sequestration, providing a clinical perspective on how ...
Nadine Best, Gizem Karabiyik, Gerd Geerling, Sarah Barbara Zwingelberg, Gregor Lang, Martin Humenik   +5 more
wiley   +1 more source

Ingestion of amoxicillin–clavulanic acid at therapeutic concentration during blood meal impacts Aedes aegypti microbiota and dengue virus transmission

Scientific Reports
Dengue virus (DENV), mainly transmitted by Aedes aegypti mosquitoes, is the most prevalent arbovirus worldwide, representing a public health problem in tropical and subtropical countries. In these areas, antibiotic consumption rises which may impact both
Margot Garcia--Van Smévoorde, Elodie Calvez, Isaure Quétel, Christelle Dollin, Sébastien Breurec, Anubis Vega-Rúa   +5 more
doaj   +1 more source

Integrated Reservoir Characterisation in a Carbonate Reservoir

EAGE/SPE Joint Workshop - Well Testing and Seismics, 2009
In this large carbonate platform reservoir, there are two distinct regions identifiable from seismic data: platform interior and raised margin.
openaire   +2 more sources

Tuning the Testicular Microenvironment for Enhancing Human Sertoli Cells Maturation and Functionality In Vitro

Advanced Healthcare Materials, EarlyView.
An in vitro testicular model is developed by generating connective tissue equivalents from human dermal fibroblast‐derived microtissues and coupling them with human Sertoli cells or human Sertoli cell spheroids. This engineered microenvironment supports Sertoli cell maturation and functionality, providing a promising platform for studying human ...
Annachiara Scalzone, Giorgia Imparato, Chiara Ausilio, Valentina Mollo, Paolo Antonio Netti   +4 more
wiley   +1 more source