Results 241 to 250 of about 859,026 (323)

Single‐Cell Atlas of Subchondral Bone Marrow Lesions Reveals Proteostasis Dysfunction as a Druggable Mechanism for Early Osteoarthritis

open access: yesAdvanced Science, EarlyView.
This study reveals that abnormal mechanical stress downregulates the expression of HSP70 and impairs proteasome function in osteoarthritic bone cells, leading to misfolded collagen I accumulation and ER stress. When intracellular proteostasis capacity is exceeded, USP19 mediates the secretion of misfolded proteins into the extracellular space ...
Hailun Xu   +20 more
wiley   +1 more source

Inside the Microreactor: In Situ Real‐Time Observation of Vapor–Liquid–Solid Growth of Monolayer TMDCs

open access: yesAdvanced Science, EarlyView.
In situ observation of VLS growth in a confined microreactor reveals various growth modes of monolayer TMDCs, including abnormal ribbon growth and particle‐driven growth. The confined space and precursor balance influence droplet behavior and growth dynamics, offering new insights into the controlled synthesis of TMDCs via the VLS mechanism.
Hiroo Suzuki   +6 more
wiley   +1 more source

IgG‐Bridging–Seeded Synergistic Aggregation of SARS‐CoV‐2 Spikes Underlies Potent Neutralization by a Low‐Affinity Antibody

open access: yesAdvanced Science, EarlyView.
Low‐affinity antibodies are frequently disregarded in discovery pipelines. This work reports P5‐1C8, a Class 1 SARS‐CoV‐2 antibody with weak trimer binding (KD‐to‐IC50 > 3700‐fold) yet potent neutralization of Omicron JN.1. Structural, biophysical, functional, and coarse‐grained simulations collectively demonstrate that transient inter‐spike IgG ...
Niannian Lv   +29 more
wiley   +1 more source

Application of membrane processes for expressway rainwater runoff treatment and reuse. [PDF]

open access: yesSci Rep
Tałałaj IA   +8 more
europepmc   +1 more source

Lithium Squarate as Sacrificing Electrolyte Additive for Prelithiation: Case Study in Zero‐Excess Lithium Metal Batteries

open access: yesAdvanced Science, EarlyView.
Active lithium loss (ALL) and capacity fade can be compensated by prelithiation, apparently simple via sacrificing additives e.g., lithium squarates. However, as a cathode additive it ruptures the cathode via gas evolution, while as an electrolyte additive it gets reductively depleted on anode side in course of solid electrolyte interphase (SEI ...
Ibrahim Lawan Abdullahi   +8 more
wiley   +1 more source

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