Results 81 to 90 of about 293,075 (266)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Modelagem geoestatística da infecção por Ascaris lumbricoides

Cadernos de Saúde Pública
O estudo tem por objetivo modelar a distribuição espacial da ocorrência de ascaríase, utilizando mapas de risco mediante técnicas de geoprocessamento e análise geoestatística.
Bruno de Paula Menezes Drumond Fortes, Luis Iván Ortiz Valencia, Simone do Vale Ribeiro, Roberto de Andrade Medronho   +3 more
doaj  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Spatial distribution of leprosy cases in Ribeirão Preto, Brazil, 2004 Distribución espacial de casos de hanseniasis en el municipio de Ribeirão Preto para el año 2004 Distribuição espacial dos casos de hanseníase no município de Ribeirão Preto no ano de 2004

Revista Latino-Americana de Enfermagem, 2007
This cross-sectional study aimed to describe the spatial distribution of leprosy cases in Ribeirão Preto in 2004. The data collection was performed through compulsory notification records in the Epidemiological Surveillance Service of the Municipal ...
Juliana Silva Gauy, Paula Hino, Claudia Benedita dos Santos   +2 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Factors Affecting Sustainable Market Acceptance of Residential Microgeneration Technologies. A Two Time Period Comparative Analysis

Energies, 2019
On a global scale, the residential sector is responsible for a significant part of consumed energy, of which the major part is dependent upon fossil fuels.
Spyridon Karytsas, Ioannis Vardopoulos, Eleni Theodoropoulou   +2 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Freqüência e distribuição espacial de Aedes aegypti e Aedes albopictus (Diptera, Culicidae) no Rio de Janeiro, Brasil

Cadernos de Saúde Pública
No presente estudo, procuramos avaliar a freqüência de Aedes aegypti e Ae. albopictus dentro e fora das casas de bairros urbanos, suburbanos e rurais nos municípios de Nova Iguaçu e Rio de Janeiro, Brasil, no período de agosto de 2002 a julho de 2004.
Tamara Nunes de Lima-Camara, Nildimar Alves Honório, Ricardo Lourenço-de-Oliveira   +2 more
doaj  

Social Determinants of Health in Pediatric Asthma and Allergic Diseases: A Systematic Review

Epidemiologia
Objectives: This study aimed to synthesize evidence of the influence of multilevel social determinants of health (SDOHs) on asthma and allergic disease outcomes and healthcare utilization in children and adolescents, with a specific focus on how these ...
Despoina Koumpagioti, Dafni Moriki, Barbara Boutopoulou, Pantelis Perdikaris, Konstantinos Douros   +4 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source