Results 101 to 110 of about 19,252,089 (389)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Understanding Lake Residence Time Across Spatial and Temporal Scales: A Modeling Analysis of Lake George, New York USA

Water Resources Research
Whole lake residence time has been associated with various water quality parameters, including harmful algal blooms. Despite observations of spatial variability in commonly measured lake water quality parameters, little attention is given to the spatial ...
Guillaume A. R. Auger, Michael R. Kelly, Vincent W. Moriarty, Kevin C. Rose, Harry R. Kolar   +4 more
doaj   +1 more source

On-site residence time in a driven diffusive system: violation and recovery of mean-field

, 2016
We investigate simple one-dimensional driven diffusive systems with open boundaries. We are interested in the average on-site residence time defined as the time a particle spends on a given site before moving on to the next site. Using mean-field theory,
MacKintosh, Fred C., Messelink, Joris J. B., Rens, Robbie, Sharma, Abhinav, Vahabi, Mahsa   +4 more
core   +1 more source

Defending against Co-residence Attack in Energy-Efficient Cloud: An Optimization based Real-time Secure VM Allocation Strategy [PDF]

, 2022
Lu Cao, Ruiwen Li, Xiaojun Ruan, Yuhong Liu   +3 more
openalex   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Nanocarbons from acid pretreated waste coffee grounds using microwave radiation [PDF]

, 2017
This study investigates the use of microwave radiation to produce nanocarbons from Waste Coffee Grounds (WCG). It is first step to demonstrate the potential of integrating the microwave power to conventional methods of carbonaceous materials and ...
Gyamera, Benjamin Asenso, Skoulou, Vasiliki K., Zein, Sharif H.   +2 more
core   +1 more source

Redfield Ratios in Inland Waters: Higher Biological Control of C:N:P Ratios in Tropical Semi-arid High Water Residence Time Lakes

Frontiers in Microbiology, 2017
The canonical Redfield C:N:P ratio for algal biomass is often not achieved in inland waters due to higher C and N content and more variability when compared to the oceans. This has been attributed to much lower residence times and higher contributions of
N. H. They, A. Amado, J. Cotner
semanticscholar   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Fractional time random walk subdiffusion and anomalous transport with finite mean residence times: faster, not slower

, 2012
Continuous time random walk (CTRW) subdiffusion along with the associated fractional Fokker-Planck equation (FFPE) is traditionally based on the premise of random clock with divergent mean period.
A. Chechkin, A. N. Kolmogorov, B. D. Hughes, D. ben-Avraham, I. Goychuk, I. Podlubny, Igor Goychuk, J. Feder, R. Kubo   +8 more
core   +1 more source

Predicting Residence Time and Drug Unbinding Pathway through Scaled Molecular Dynamics

Journal of Chemical Information and Modeling, 2018
Computational approaches currently assist medicinal chemistry through the entire drug discovery pipeline. However, while several computational tools and strategies are available to predict binding affinity, predicting the drug-target binding kinetics is ...
D. Schuetz, Mattia Bernetti, Martina Bertazzo, D. Musil, H. Eggenweiler, M. Recanatini, Matteo Masetti, G. Ecker, A. Cavalli   +8 more
semanticscholar   +1 more source