Results 251 to 260 of about 186,237 (325)

Microfluidic Concentration Manipulation via Controllable AC Electroosmotic Flow. [PDF]

Micromachines (Basel)
Lv J, Pei Y, Sun J.
europepmc   +1 more source

The Mitochondrial Guardian α‐Amyrin Mitigates Alzheimer's Disease Pathology via Modulation of the DLK‐SARM1‐ULK1 Axis

Advanced Science, EarlyView.
Dietary habits play a key role in chronic diseases, and higher annual consumption of fruit and vegetable may lower risk of dementia. Artificial intelligence predicts the lipid‐like compound α‐Amyrin (αA) from plants with edible peels as a drug candidate against Alzheimer's disease.
Shu‐Qin Cao, Juan Ignacio Jiménez‐Loygorri, Yunguang Qiu, You Jung Kang, Khanh Van Do, Annabel E. Smith, Junjie Huang, Jun‐ping Pan, Lipeng Mao, Ang Li, Hangge Yang, Yahyah Aman, Maria Jose Donate Lagartos, Sofie Hindkjær Lautrup, Anbin Chen, Kristina Xiao Liang, Hailong Zhang, Juan Yi, Xurui Jin, Tin Cho Cheung, Olympia Apokotou, Florentia Papastefanaki, Rebecca Matsas, William A. McEwan, Feixiong Cheng, Hansang Cho, Guobing Chen, Huanxing Su, Konstantinos Palikaras, Oscar Junhong Luo, Qian Hua Zhao, Ding Ding, Cornelia van Duijn, Nektarios Tavernarakis, Patricia Boya, Tewin Tencomnao, Evandro F. Fang   +36 more
wiley   +1 more source

Mathematical Modeling of Local Drug Delivery in the Oral Cavity: From Release Kinetics to Mini-PBPK and Local PK/PD with Applications to Periodontal Therapies. [PDF]

Pharmaceutics
Rakoczy R, Machoy-Rakoczy M, Gutowska I.
europepmc   +1 more source

CD27 and ICOS as Targets of PD‐1/PD‐L1 Signaling to Regulate Resident Memory CD8+ T‐Cell‐Mediated Pulmonary Protection and Pathology

Advanced Science, EarlyView.
Here it is revealed that the costimulatory receptors CD27 and ICOS are essential for the long‐term maintenance of PD‐1high CD8+ TRM cells following influenza infection. PD‐L1 blockade enhances the proliferation and activation of these cells through Nur77 activation downstream of the CD27/ICOS signaling axis, thereby boosting host immunity against ...
Yuanyuan Chen, Zhenzhen Wang, Liqiang Song, Qianqian Chen, Hang Zhang, Tao Pan, Jianli Pan, Sheng Zhao, Ting Shang, Hong'en Xu, Xing Lv, Jing Li, Fei Kang, Yongzhan Nie, Feng Zhao, Lei Shi, Zheng Wang   +16 more
wiley   +1 more source

Mechanistic Analysis of Fluid Dynamics and Multifactorial Impact Mechanisms in Inhaled Pharmaceutical Deposition for Chronic Respiratory Diseases. [PDF]

Bioengineering (Basel)
Hu F, Ma S, Hu T.
europepmc   +1 more source

A Self‐Organized Liquid Reaction Container for Cellular Memory

Advanced Science, EarlyView.
How cells restore epigenetic information lost during replication is not known. This work proposes a mechanism based on the formation of biomolecular condensates. These condensates are induced by the chromosome itself and serve as reaction vessels for reconstructing missing epigenetic markers.
Sukanta Mukherjee, Enrico Skoruppa, Holger Merlitz, Jens‐Uwe Sommer, Helmut Schiessel   +4 more
wiley   +1 more source

Influence of Hydrogen-Based Direct Reduction Shaft Furnace Interior Structure on Shaft Furnace Performance. [PDF]

Materials (Basel)
Xue Q, Liao H, Zhang J, Li K.
europepmc   +1 more source

Turbulent Flow in Street Canyons: A Complexity Approach. [PDF]

Entropy (Basel)
Hubay CÁ, Papp B, Kalmár-Nagy T.
europepmc   +1 more source

Voronoi-based analysis of clustering dynamics in experimental volcanic ash clouds. [PDF]

Bull Volcanol
Capponi A, Cimarelli C, Mininni P.
europepmc   +1 more source

Bio-inspired ultrasonic microreactor for efficient synthesis of indigo-emitting carbon dots with tunable morphology and enhanced optical properties. [PDF]

Ultrason Sonochem
Rao L, Zhu S, Liu J, Bai Q, Zou J, Deng C, Tu H, Liu Q, Zhong G, Niu X, Li J.   +10 more
europepmc   +1 more source