Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Anatomic Knowledge and Perceptions of the Adequacy of Anatomic Education Among Applicants to Orthopaedic Residency. [PDF]
, 2017 BackgroundThe time dedicated to the study of human anatomy within medical school curriculums has been substantially reduced. The effect of this on the knowledge of incoming orthopaedic trainees is unknown.
Acosta, Anna +7 more
core
Teaching the Emergency Department Patient Experience: Needs Assessment from the CORD-EM Task Force. [PDF]
, 2016 INTRODUCTION: Since the creation of Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) patient satisfaction (PS) scores, patient experience (PE) has become a metric that can profoundly affect the fiscal balance of hospital systems,
Druck, Jeffrey +3 more
core +3 more sources
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Governor Hassan Remains Popular; Granite Staters Support 30 Day Residency Requirement For Voting 7/21/15 [PDF]
, 2015 Governor Maggie Hassan continues to be popular in the state and is strongly positioned for reelection, should she decline to run for the US Senate. A majority of New Hampshire residents approve of a bill to establish a 30 day residency requirement in ...
Survey Center, UNH
core +1 more source
Characteristics of successful interventions to reduce turnover and increase retention of early career nurses: a systematic review [PDF]
, 2018 Background nurse shortages have been identified as central to workforce issues in healthcare systems globally and although interventions to increase the nursing workforce have been implemented, nurses leaving their roles, particularly in the first year ...
Aitken, L. M. +4 more
core +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
2008 Survey of the Performance of American Elections: Final Report [PDF]
, 2009 Analyzes results of a survey on the 2008 elections voting experience, voter confidence in the system, reasons for not voting, and support for reform proposals.
Adam Berinsky +5 more
core
Checkpoint blockade and the stem‐like T cell trade‐off
Molecular Oncology, EarlyView.Stem‐like T cells are key to the success of programmed cell death protein 1 (PD1) blockade, as they sustain long‐term anti‐tumor response by continuously generating effector CD8+ T cells. However, how these cells are maintained in cancer is not fully understood. Hor et al.
Julie M. Mazet, Johanna A. Joyce
wiley +1 more source
The effect of a structured internship on the clinical performance of novice nurses? [PDF]
, 2014 Objective: The study examined the clinical performance differences of novices before and after a critical care internship and compare their performance attributes to a reference group comprised of experienced critical care nurses.
Hauber, Roxanne +2 more
core +1 more source