Results 201 to 210 of about 817,240 (334)

Genome‐Wide CRISPR Screen Reveals PIK3CA Inhibition Enhances Lipid Nanoparticle‐Mediated siRNA Delivery

open access: yesAdvanced Science, EarlyView.
A genome‐wide CRISPR screen and identifies PIK3CA as a key regulator of lipid nanoparticle (LNP) uptake is performed. Modulating PIK3CA with small‐molecule inhibitor BAY1082439 enhanced LNP uptake, siRNA delivery, and gene silencing in a variety of epithelial cells, and improved therapeutic outcomes in vivo.
Wenhan Wang, Kangfu Chen, Zongjie Wang
wiley   +1 more source

Season-Based Occupancy Prediction in Residential Buildings Using Machine Learning Models

open access: gold, 2021
Bowen Yang   +3 more
openalex   +1 more source

Endothelial Cell‐Based Vascular Bandages for Blood–Brain Barrier Repair and Targeted siRNA Delivery

open access: yesAdvanced Science, EarlyView.
mECs restore blood–brain barrier function after cerebral ischemia–reperfusion by simultaneously targeting, supporting, and regulating the damaged vasculature. mECs home to injured cerebral vessels through interactions with highly expressed VLA‐4, reinforce endothelial integrity by forming new junctions, and, upon OGD‐SN treatment, acquire enhanced ...
Yaosheng Li   +23 more
wiley   +1 more source

Truncated Conjugate Structure Improves Solar‐Driven Hydrogen Peroxide Production Catalyzed by Benzobisthiazole‐Based Conjugated Polymers

open access: yesAdvanced Science, EarlyView.
In this work, a novel molecular design strategy was employed to truncate large‐scale conjugated structures in covalent polymer materials. This approach significantly enhances the catalyst’s light‐harvesting capability, prolongs the lifetime of photogenerated charge carriers, and improves catalytic activity, thereby offering a new conceptual pathway for
Cui Li   +4 more
wiley   +1 more source

Scalable Photoactive NO2‐Sensing Framework for Plant Health Monitoring

open access: yesAdvanced Science, EarlyView.
A highly sensitive and selective NO2 gas sensor operates at room temperature using only ambient light, eliminating the need for external heating. Based on a scalable, 3D TiO2 nanoarchitecture, the device is integrated into a wireless platform and deployed on a plant. It successfully demonstrates real‐time monitoring of gas‐induced physiological stress,
Yun‐Haeng Cho   +21 more
wiley   +1 more source

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