Results 61 to 70 of about 853 (195)

ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology

Advanced Science, EarlyView.
This study identifies that ALKBH3‐driven m1A demethylation orchestrates Alzheimer's disease progression by disrupting mitochondrial and synaptic homeostasis. This epitranscriptomic mechanism suppresses PINK1‐mediated mitophagy via m1A erasure, leading to mitochondrial dysfunction, oxidative stress, elevated Aβ production, and impaired microglial ...
Yueyang Li, Sifei Yu, Kaidong Lu, Yujie Zhang, Mingjie Dong, Yan Peng, Liang Xue, Waleed Alam, Yuxuan Shui, Yi Zhou, Wuyunhan Ma, Meng Bao, Peiming Li, Peiyi Luo, Tiezhan Lu, Jiajia Li, Kang Zhang, Yuying Wang, Shuchen Yang, Nuoya Yin, Francesco Faiola, Zilong Gao, Jingfeng Zhou, Fei Zhao, Yali He, Magdalena J. Koziol   +25 more
wiley   +1 more source

Modular Generation of Alkyl Selenyl Radicals for the Synthesis of Alkyl Selenides via a Mechanochemical Approach

Advanced Science, EarlyView.
We present a mechanochemical, radical‐mediated hydroselenation of alkenes under ambient conditions. This method modularly generates alkyl selenyl radicals from elemental selenium and alkyl (pseudo)halides, utilizing PhSiH3 and H2O as hydrogen atom donors, with the water likely originating from the air and/or trace water present in the reagents ...
Xiaochun He, Yu Zhou, Fei Zhou, Zixi Ai, Peiyu Hu, Xuemei Zhang, Xiaofeng Wei, Gui‐Juan Cheng, Zhong Lian   +8 more
wiley   +1 more source

Review: Insight on Porous Carbon Positive Electrode for Sodium‐Ion Capacitors: Interplay Between Synthesis, Properties, and Performance

Advanced Science, EarlyView.
Sodium ion capacitor (SIC) is currently constrained by the low discharge capacity of commercial activated carbon as positive electrode material. This review provides a holistic summary of research efforts on alternative porous carbon materials for SIC. Image created by the authors with www.biorender.com.
Ademola Adeniji, Adrian Beda, Camélia Matei Ghimbeu   +2 more
wiley   +1 more source

GPX4 Inhibitor Resistance and Metastatic Features in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study establishes breast cancer cell lines that are resistant to glutathione peroxidase 4 inhibitors (GPX4i) in vitro and investigates the metastatic capacity of the GPX4i‐resistant versus parental lines in vivo. GPX4i‐resistant cells survive upon intravenous injection, but lose capacity to spontaneously metastasize.
Marie Sabatier, Mayher Kaur, Milena Chaufan, Felix‐Levin Hormann, Luiza Martins Nascentes Melo, Mario Palma, Jordan Torpey, Yanshan Liang, Alanis Carmona, Cameron Fraser, Midori Flores, Krystina J. Szylo, Mahsa Yavari, Sheng Hui, Alpaslan Tasdogan, Sven Heiles, Jessalyn M. Ubellacker   +16 more
wiley   +1 more source

Self‐Healing Starch‐Based Ionogels with Hydroneutral Dipole–Dipole Interactions

Advanced Science, EarlyView.
This work introduces starch‐based, conductive, underwater‐healable, and transparent ionogels for soft electronics (SCUTEs). Starch macromolecules are partially substituted with cyanoethyl groups and incorporated with hydrophobic ionic liquid. The polar yet hydroneutral cyanoethyl groups facilitate strong dynamic dipole–dipole interactions that remain ...
J. Justin Koh, Jiayi Liu, Xue Qi Koh, Binting Huang, Szu Cheng Lai, Jayce Jian Wei Cheng, Gwendolyn J. H. Lim, Warintorn Thitsartarn, Yong‐Wei Zhang, Zhigen Yu, Chaobin He   +10 more
wiley   +1 more source

Design of Optical Transducer for Recognition of Biomolecular Interactions between Bacterial Lipopolysaccharides and Amino Acids

Advanced Science, EarlyView.
A deep comprehension of biomolecular phenomena at interfaces is significant with their fundamental and practical importance. Our experimental and theoretical investigations reveal that specific amino acids (glutamic acid and aspartic acid) exhibit an orientational coupling with liquid crystals, which can recognize and optically report the interfacial ...
Yena Choi, Sangmin Lee, Jin‐Kang Choi, Hyunsoo Han, Yeongseon Choi, Jun‐Hyung Im, Hyein Kim, Sangmin Jeon, Minjae Lee, Chang Yun Son, Young‐Ki Kim   +10 more
wiley   +1 more source

Multifunctional Phosphate Monomer Enabling LiNO3 Solvation and In Situ Formation of Flame‐Retardant Gel Polymer Electrolyte for High‐Voltage Lithium Metal Batteries

Advanced Science, EarlyView.
A phosphorus‐containing multifunctional monomer is successfully synthesized to simultaneously enable the dissolution of lithium nitrate in ester‐based electrolytes and in situ form a flame‐retardant gel polymer electrolyte (GPE). The formed GPE effectively stabilizes the structures of both the cathode and anode, thereby achieving superior long‐term ...
Lijun Ma, Lu Lu, Tianqi Xiang, Yaxin Wang, Jianjun Zhou, Lin Li   +5 more
wiley   +1 more source

Electro‐Chemo‐Mechanical Coupling in Composite Cathodes of Sulfide‐Based All‐Solid‐State Batteries: Pathways, Degradation, and Design Rules

Advanced Science, EarlyView.
This review provides an integrated framework for achieving superior electrochemical performance in sulfide‐based all‐solid‐state batteries. It first delineates mechano‐electrochemical failure modes of cathode active materials and solid electrolytes, then outlines engineering principles for particle morphology, electronic and ionic conduction, and ...
Gawon Song, Seonghyun Lee, Minseon Lee, Junsung Park, Kyu Tae Lee   +4 more
wiley   +1 more source

Customizing Tactile Sensors via Machine Learning‐Driven Inverse Design

Advanced Science, EarlyView.
ABSTRACT Replicating the sophisticated sense of touch in artificial systems requires tactile sensors with precisely tailored properties. However, manually navigating the complex microstructure‐property relationship results in inefficient and suboptimal designs.
Baocheng Wang, Depeng Kong, Zhiao He, Jikai Liang, Yuyao Lu, Zikang Deng, Honghe Li, Mengke Wang, M. Jamal Deen, Zhiqiu Ye, Shuyao Zhou, Huayong Yang, Honghao Lyu, Jun Chen, Kaichen Xu, Geng Yang   +15 more
wiley   +1 more source

Electrocatalytic C─N Coupling in Aqueous Solutions for High‐Value Product Synthesis

Angewandte Chemie, EarlyView.
Electrocatalytic C–N coupling offers a sustainable route to synthesize crucial organic nitrogen compounds from abundant feedstocks under mild conditions. This review examines recent progress in overcoming key challenges, like slow kinetics and competing reactions through advanced catalysts and novel mechanisms, paving the way for transforming chemical ...
Yunpeng Zuo, Dongxue Yu, Xiaoran Zhang, Xin Wang   +3 more
wiley   +2 more sources