Results 51 to 60 of about 2,046,961 (289)
Metals, 2018 Rolling back-up rolls require high fracture toughness, particularly in the shaft portion, and high-hardness in the sleeve portion. The rolls are classified into two types; one is an integrated type and the other is a shrink-fitted type consisting of a ...
N. Noda +4 more
semanticscholar +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Optimized prediction model for concrete dam displacement based on signal residual amendment
, 2020 The traditional statistical model of concrete dam's displacement monitoring is used widely in hydraulic engineering. However, the forecasting precision of the conventional calculation model is poor due to the antiquated method of information mining and ...
Bowen Wei +4 more
semanticscholar +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Orthopaedic SurgeryObjective Currently, quality criteria for reduction after femoral neck fractures such as the Garden index are mainly based on two‐dimensional x‐rays. Research shows that current reduction quality criteria are no longer sufficient to meet the needs to ...
Shuang‐Shuang Cui +4 more
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
ANALYSES OF RESIDUAL DISPLACEMENT AT EARTHQUAKE-DAMAGED PIERS
Doboku Gakkai Ronbunshu, 1999 被災橋脚に生じた残留変位の特徴を明らかにするために, 残留変位の地域分布や方向性について分析した. その結果, 橋脚の残留変位は, 橋軸方向で神戸側, 橋軸直角方向で山側に残留している橋脚が多く, 変位量が大きいものは被災地域の東側で多く認められた. また, 橋軸直角方向の橋脚残留変位と上部工と橋脚の偏心量の間には相関性が認められた. ついで, 残留変形が大きな被災地域東側を対象に, 航空写真を用いた分析による, 地盤, 建物, 桁と橋脚の残留変位を比較した結果, エリアごとのばらつきはあるものの, ほぼ神戸方向に残留する傾向が認められた.
Kenji KOSA +3 more
openaire +2 more sources
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source