Results 51 to 60 of about 17,083 (261)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Seismic Performance and Sustainability of BRB and SMA-Braced Structures Under Incremental Dynamic Analysis

Journal of Sustainability
Buckling restrained braces (BRBs) are widely used for seismic resistance due to their efficiency and stable structural behaviour. However, despite their high energy dissipation capacity, BRBs retain residual strains, leading to permanent deformations ...
Ramin Mardi, Amirhossein Ostovar
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

ANALYSES OF RESIDUAL DISPLACEMENT AT EARTHQUAKE-DAMAGED PIERS

Doboku Gakkai Ronbunshu, 1999
被災橋脚に生じた残留変位の特徴を明らかにするために, 残留変位の地域分布や方向性について分析した. その結果, 橋脚の残留変位は, 橋軸方向で神戸側, 橋軸直角方向で山側に残留している橋脚が多く, 変位量が大きいものは被災地域の東側で多く認められた. また, 橋軸直角方向の橋脚残留変位と上部工と橋脚の偏心量の間には相関性が認められた. ついで, 残留変形が大きな被災地域東側を対象に, 航空写真を用いた分析による, 地盤, 建物, 桁と橋脚の残留変位を比較した結果, エリアごとのばらつきはあるものの, ほぼ神戸方向に残留する傾向が認められた.
Kenji KOSA, Kouichi ONO, Yasuo FUJII, Katunori TANAKA   +3 more
openaire   +2 more sources

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Inversions of Surface Displacements in Scaled Experiments of Analog Magma Intrusion

Geophysical Research Letters
Standard geodetic models simplify magma sheet injection to the opening of geometrically simple dislocations in a linearly elastic, homogeneous medium. Intrusion geometries are often complex, however, and non‐elastic deformation mechanisms can dominate ...
S. Poppe, C. Wauthier, K. Fontijn
doaj   +1 more source

Large-Scale Testing of a Novel Self-Centering Brace with U-Shaped Plates for Seismic Energy Dissipation

CivilEng
Energy-dissipating braces are novel structural components as they not only accommodate the seismic energy demand but also enhance both the flexibility and overall earthquake resistance of the structure, preventing brittle or non-ductile behavior.
Onur Gurler, Ozgur Ozcelik, Sadik Can Girgin, Atakan Aksoy, Cagri Cetik   +4 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source