Results 71 to 80 of about 17,083 (261)

Development of a magnetic composite material for measurement of residual limb displacements in prosthetic sockets

Journal of Rehabilitation and Assistive Technologies Engineering, 2018
Introduction Wearable limb–socket displacement sensors may help patients and prosthetists identify a deteriorating socket fit and justify the need for repair or replacement.
Ethan J Weathersby, John C Cagle, Brian G Larsen, Katrina M Henrikson, Joan E Sanders   +4 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Digital Image Correlation for Elastic Strain Evaluation during Focused Ion Beam Ring-Core Milling

Journal of Manufacturing and Materials Processing
This paper details the utilization of the focused ion beam digital image correlation (FIB-DIC) technique for measuring in-plane displacements and the employment of the height digital image correlation (hDIC) technique as a two-step DIC method for ...
Fatih Uzun, Alexander M. Korsunsky
doaj   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Experimental Investigation of Granular Soil and Clay Interfaces with Direct Shear Tests

Geotechnics
This study experimentally investigates the shear strength behavior of interfaces formed between granular soils and clay under drained conditions, with particular emphasis on peak-to-residual strength evolution.
Sevki Ozturk, Mehmet Ufuk Ergun
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Numerical Investigation on Cyclic Behavior of FRP-Reinforced SFRC Composite Walls Considering Bond-Slip Mechanism

Buildings
To investigate the cyclic behavior of FRP-reinforced steel fiber reinforced concrete (SFRC) composite walls, this paper proposes a section-based finite spring calculation method (FSCM) to reliably predict the cyclic response of such walls under seismic ...
Mingyuan Liu, Jun Tian, Jianwen Liang, Yuping Sun, Ziran Quan   +4 more
doaj   +1 more source

Displacement residuals reveal landslide regime shifts

Landslides
AbstractDespite significant progress in the development of advanced technologies for detecting and monitoring unstable slopes, accurately predicting catastrophic landslides remains a challenge. To tackle this challenge, our research integrates advanced prediction models and granular systems theory to provide insights into regime shifts within slow ...
Nava, Lorenzo, Tordesillas, Antoinette, Qian, Guoqi, Catani, Filippo   +3 more
openaire   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source