Results 161 to 170 of about 125,543 (299)

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

A Robust 3D Registration Method via Simultaneous Inlier Identification and Model Estimation. [PDF]

J Imaging
Qian X, Wen F, Liu P.
europepmc   +1 more source

Description of program using maximum likelihood residual for macromolecular refinement, illustrated by several examples [PDF]

Acta Crystallographica Section A Foundations of Crystallography, 1996
E. J. Dodson, G. N. Murshudov, A. A. Vagin   +2 more
openaire   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Residual Error Coding in NONMEM Can Mislead Diagnostic Residuals: Impact of W Definition on IWRES, WRES, and CWRESI. [PDF]

Pharmaceutics
Simon N, von Fabeck K.
europepmc   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Heterogeneity in Panel Data: Are There Stable Production Functions? [PDF]

We estimate separate productions functions for approximately 450 manufacturing firms each in France and the United States and for 850 manufacturing firms in Japan, covering the 13 year period 1967-1979, and focus on the wide dispersion in the estimated ...
Zvi Griliches, Jacques Mairesse
core  

Multivariate Birnbaum-Saunders accelerated lifetime regression model: estimation and residual analysis. [PDF]

Sci Rep
Oliveira MI, Cysneiros FJA, Barros M.
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Modified whittle estimation of multilateral spatial models [PDF]

We consider the estimation of parametric models for stationary spatial or spatio-temporal data on a d-dimensional lattice, for d = 2. The achievement of asymptotic efficiency under Gaussianity, and asymptotic normality more generally, with standard ...
Peter Robinson, J. Vidal Sanz
core