Results 141 to 150 of about 125,543 (299)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Testing Substitution Bias of the Solow-Residual Measure of Total Factor Productivity Using CES-Class Production Functions [PDF]
Total factor productivity (TFP) computed as Solow-residuals could be subject to input-substitution bias for two reasons. First, the Cobb-Douglas (CD) production function restricts all input substitutions to one.
Peter A. Zadrozny, Baoline Chen
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Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Modified Whittle estimation of multilateral models on a lattice. [PDF]
In the estimation of parametric models for stationary spatial or spatio-temporal data on a d-dimensional lattice, for d≥2, the achievement of asymptotic efficiency under Gaussianity, and asymptotic normality more generally, with standard convergence rate,
Robinson, P.M., Vidal-Sanz, Jose M.
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Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source
Multi-dimensional Point Process Models in R
A software package for fitting and assessing multidimensional point process models using the R statistical computing environment is described. Methods of residual analysis based on random thinning are discussed and implemented.
Roger Peng
core
Modelling Truncated and Clustered Count Data
, 2005 Count response data often exhibit departures from the assumptions of standard Poisson generalized linear models (McCullagh & Nelder 1989). In particular, cluster level correlation of the data and truncation at zero are two common characteristics of ...
Saei, Ayoub, Chambers, Ray
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FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source
Estimasi parameter model Vector Autoregressive dengan metode Maximum Likelihood [PDF]
, 2018 INDONESIA: Model Vector Autoregressive (VAR) merupakan pemodelan time series multivariate yang memiliki beberapa variabel endogen secara bersamaan, namun masing-masing variabel endogen dijelaskan oleh lag dari nilainya sendiri dan variabel endogen ...
Jannah, Roikhatul
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