Results 41 to 50 of about 885,756 (290)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Optimizing option pricing: Exact and approximate solutions for the time-fractional Ivancevic model

Alexandria Engineering Journal, 2023
This research investigates the time fractional Ivancevic option pricing model and presents two distinct solution methods: the invariant subspace method for obtaining exact solutions and the residual power series method for generating approximate ...
Khalid K. Ali, M.A. Maaty, M. Maneea
doaj   +1 more source

Estimación del precio marginal del sistema eléctrico colombiano: una mirada desde la organización industrial [PDF]

, 2015
We analyze the behavior of spot prices in the Colombian wholesale power market, using a series of models derived from industrial organization theory -- We first create a Cournot-based model that simulates the strategic behavior of the market-leader power
Duarte Venslauskas, Ona, García Rendón, John J.   +1 more
core   +2 more sources

A residual power series technique for solving Boussinesq–Burgers equations

Cogent Mathematics, 2017
AbstractIn this paper, a residual power series method (RPSM) is combining Taylor’s formula series with residual error function, and is investigated to find a novel analytical solution of the coupled strong system nonlinear Boussinesq-Burgers equations according to the time.
Bewar A. Mahmood, Majeed A. Yousif
openaire   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Solving Boundary-Layer Problems by Residual-Power-Series Method

Journal of Mathematics Research, 2016
<p><span lang="EN-US">In this paper, the so-called residual-power-series (RPS) method is presented for solving nonlinear boundary-layer equations. The RPS method provides a single unified treatment for the linear and nonlinear terms in the equations.
openaire   +2 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Closed-form solutions of higher order parabolic equations in multiple dimensions: A reliable computational algorithm

Alexandria Engineering Journal, 2023
Parabolic equations play an important role in chemical engineering, vibration theory, particle diffusion and heat conduction. Solutions of such equations are required to analyze and predict changes in physical systems. Solutions of such equations require
Mubashir Qayyum, Amna Khan, Syed Tauseef Saeed, Ali Akgül, Muhammad Bilal Riaz   +4 more
doaj   +1 more source