Results 51 to 60 of about 889,604 (280)

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Closed-form solutions of higher order parabolic equations in multiple dimensions: A reliable computational algorithm

open access: yesAlexandria Engineering Journal, 2023
Parabolic equations play an important role in chemical engineering, vibration theory, particle diffusion and heat conduction. Solutions of such equations are required to analyze and predict changes in physical systems. Solutions of such equations require
Mubashir Qayyum   +4 more
doaj   +1 more source

Solving Boundary-Layer Problems by Residual-Power-Series Method

open access: yesJournal of Mathematics Research, 2016
<p><span lang="EN-US">In this paper, the so-called residual-power-series (RPS) method is presented for solving nonlinear boundary-layer equations. The RPS method provides a single unified treatment for the linear and nonlinear terms in the equations.
openaire   +2 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Residual log-periodogram inference for long-run relationships [PDF]

open access: yes, 2006
We assume that some consistent estimator of an equilibrium relation between non-stationary series integrated of order d(0.5,1.5) is used to compute residuals (or differences thereof).
Hassler, U.   +2 more
core   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Residual power series method for fractional Sharma-Tasso-Olever equation

open access: yesCommunications in Numerical Analysis, 2016
In this paper, we introduce a modified analytical approximate technique to obtain solution of time fractional Sharma-Tasso-Olever equation. First, we present an alternative framework of the Residual power series method (RPSM) which can be used simply and effectively to handle nonlinear fractional differential equations arising in several physical ...
Amit Kumar, Sunil Kumar, Mukesh Singh
openaire   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Computational study for the conformable nonlinear Schrödinger equation with cubic–quintic–septic nonlinearities

open access: yesResults in Physics, 2021
The fractional (3+1)-dimensional nonlinear Schrödinger equation with cubic–quintic–septic nonlinearities plays a significant role in the study of ultra-short pulses in highly nonlinear optical phenomena.
Hira Tariq   +6 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

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