Results 41 to 50 of about 3,224 (230)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Residual Log-Periodogram Inference for Long-Run-Relationships [PDF]

open access: yes, 2002
We assume that some consistent estimator of an equilibrium relation between non-stationary series integrated of order d E (0:5; 1:5) is used to compute residuals ˆut = yt - xt (or differences there of).
Velasco Gómez, Carlos   +3 more
core  

Closed-form solutions of higher order parabolic equations in multiple dimensions: A reliable computational algorithm

open access: yesAlexandria Engineering Journal, 2023
Parabolic equations play an important role in chemical engineering, vibration theory, particle diffusion and heat conduction. Solutions of such equations are required to analyze and predict changes in physical systems. Solutions of such equations require
Mubashir Qayyum   +4 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Computational study for the conformable nonlinear Schrödinger equation with cubic–quintic–septic nonlinearities

open access: yesResults in Physics, 2021
The fractional (3+1)-dimensional nonlinear Schrödinger equation with cubic–quintic–septic nonlinearities plays a significant role in the study of ultra-short pulses in highly nonlinear optical phenomena.
Hira Tariq   +6 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

A review of residual stress analysis using thermoelastic techniques

open access: yes, 2009
Thermoelastic Stress Analysis (TSA) is a full-field technique for experimental stress analysis that is based on infra-red thermography. The technique has proved to be extremely effective for studying elastic stress fields and is now well established.
Burguete, R.L.   +7 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Diagnostics in time series analysis [PDF]

open access: yes, 1994
The portmanteau diagnostic test for goodness of model fit is studied. It is found that the true variances of the estimated residual autocorrelation function are potentially deflated considerably below their asymptotic level, and exhibit high correlations
Warnes, Alexis, Warnes, A
core  

Residual power series method for time-fractional Schrödinger equations

open access: yesJournal of Nonlinear Sciences and Applications, 2016
Summary: In this paper, the residual power series method (RPSM) is effectively applied to find the exact solutions of fractional-order time dependent Schrödinger equations. The competency of the method is examined by applying it to the several numerical examples.
Zhang, Yu   +4 more
openaire   +2 more sources

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