Results 71 to 80 of about 138,752 (279)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Contribution of Residual Renal Function on Peritoneal Solute Transport in Dialysis Patients

, 2010
<i>Background:</i> Increased peritoneal solute transport rate (PSTR) is primarily a consequence of continuous exposure to bioincompatible glucose-based peritoneal dialysis (PD) solutions.
Chie Noiri, Akihiko Matsuda, Osamu Matsumura, Mizuki Motojima, Tomonari Ogawa, Hitoshi Katou, Tadaaki Maeda, Tetsuya Mitarai, Yousuke Tayama, Hajime Hasegawa, Kouichi Kanouzawa   +10 more
core   +1 more source

Sex-Specific Impact of Roxadustat on Residual Kidney Function in Peritoneal Dialysis Patients: A Propensity Score-Weighted Analysis

Kidney Medicine
Rationale & Objective: Roxadustat effectively improves renal anemia, but its impact on residual kidney function (RKF) preservation in continuous ambulatory peritoneal dialysis (CAPD) patients is unclear.
Simin Jiang, Guanji Zhang, Yiping Xu, Yi Li, Guanglan Li, Hongyu Li, Yuchu Liu, Siyuan Li, Jianxiong Lin, Qunying Guo, Xiao Yang, Wei Chen, Haiping Mao, Yating Wang   +13 more
doaj   +1 more source

Residual Kidney Function in Hemodialyzed Patients and Related Factors

Erciyes Medical Journal, 2019
Objective: Residual kidney function (RKF) is a strong marker of the remaining capacity of the kidneys in patients with end-stage renal disease (ESRD).
Halil Ibrahim Erdoğdu, Fatih Kara
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Residual renal function in hemodialysis patients may protect against hyperaluminemia

, 1987
Residual renal function in hemodialysis patients may protect against hyperaluminemia. We investigated 106 home hemodialysis patients whose mean [±SEM] serum aluminum (A1) concentration was 60.9 ± 4.1 µg/liter. Serum A1 concentration was inversely related
De Saintonge, D. Mark Chaput, Marsh, Frank P., Plowman, David, Butter, Keith C., Cunningham, John, Altmann, Paul   +5 more
core   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Predictors of Faster Decline of Residual Renal Function in Taiwanese Peritoneal Dialysis Patients

, 2011
OBJECTIVE: Loss of residual renal function (RRF) in peritoneal dialysis ( PD) patients is a powerful predictor of mortality. The present study was conducted to determine the predictors of faster decline of RRF in PD patients in Taiwan. METHODS: The study
LIAO, CHIA-TE;SHIAO, CHIH-CHUNG;HUANG, JENQ-WEN;HUNG, KUAN-YU;CHUANG, HSUEH-FANG;CHEN, YUNG-MING;WU, KWAN-DUN;TSAI, TUN-JUN, 廖家德;蕭志忠;黃政文;洪冠予;莊雪芳;陳永銘;吳寬墩;蔡敦仁   +1 more
core  

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source