Results 171 to 180 of about 3,340,374 (282)

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Reproducibility Materials for "Physical Comparability Alters Cross-Study Interpretation of Roughness, Hardness and Residual Stress in Rolling-Contact Fatigue"

Mohd Nizar Mhd Razali
  +4 more sources

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Horizontal welding deformation and residual stress of narrow slanted groove for thick plates

Mohammed Nour, Sherif Rashed, Ninshu Ma, Yasuo Agano, Taisuke Okumura, Masakazu Shibahara   +5 more
openalex   +1 more source

Formation and process-based adjustment of residual stresses in cold cup forward extrusion [PDF]

Manuel Friedlein, Dominik Hoffman, Michael Knaps, Marion Merklein   +3 more
openalex   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Data for revised version of Influence of Groove Type on Residual Stresses of Dissimilar Titanium Alloy T-Welded Joints

F Yuan, Fan Liu, lei wang, Yanqing Li, Hao Gu, Yu Cao, fang wang   +6 more
openalex   +2 more sources

The Influence of Quenching Parameters on the Residual Stress of Ultra-High Strength Aluminum Alloy Extrusions

Hailong Cao, Hao Wu, Qi Zhang, 陈明安, Mingdong Huang, Xiao Xiang, Guojun Wang   +6 more
openalex   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Thermoelastic analogy-based finite element framework for full-field residual stress reconstruction

Junjie Tang, Yibo Gao, Fengyun Wang, Kuanmin Mao   +3 more
openalex   +1 more source