Results 71 to 80 of about 345,517 (298)
RAD50 missense variants differentially affect the DNA damage response and mitotic progression
FEBS Letters, EarlyView.RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker +9 more
wiley +1 more source
Mapping the evolution of mitochondrial complex I through structural variation
FEBS Letters, EarlyView.Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin +2 more
wiley +1 more source
MetalsTitanium alloy pressure spherical–cylindrical shells enable the effective utilization of the strength of spherical and cylindrical pressure-resistant shell components.
Yuxuan Wang +5 more
doaj +1 more source
Experimental and Numerical Studies on Residual Stress in Wide Butt Welds
Advances in Materials Science and Engineering, 2017 The presence of residual stress in steel members can significantly compromise the stiffness and fatigue life of steel structural components. This influence becomes more serious for the wide butt welds in the construction of large-sized steel members due ...
Yang Ding +3 more
doaj +1 more source
On Residual Stresses in Arteries [PDF]
Journal of Biomechanical Engineering, 1986 Yuan-Cheng Fung, Cheng Jen Chuong
openaire +3 more sources
FEBS Letters, EarlyView.Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia +5 more
wiley +1 more source
THE DETERMINNATION OF RESIDUAL STRESS OF GEAR TOOTH ROOT BASED ON X-RAY TECHNOLOGY
Jixie qiangdu, 2017 Transverse residual stress of tooth root has significant influence on bending fatigue strength of gears.But given the geometry of gears,using the method of exposing teeth root to complete determination of transverse residual stress at present,it not only
WANG Zhen +3 more
doaj
Journal of Mechanics, 2001 ABSTRACTA technique for inverting residual stress based on a theory of acoustoelasticity is presented. A general incremental constitutive relation is first derived for a pre-stressed material subjected to an additional infinitesimal elastic deformation.
H. T. Lee, Mao-Kuen Kuo
openaire +2 more sources
FEBS Letters, EarlyView.Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur +5 more
wiley +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source