Results 41 to 50 of about 61,819 (240)
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Residual stresses and fatigue resistance of toothed wheels
Вестник Самарского университета: Аэрокосмическая техника, технологии и машиностроение, 2018 Residual stresses in the dangerous section of toothed wheels made of materials and according to practices accepted in aviation engine construction have been determined using a mechanical method. The influence of the technology of manufacturing of toothed
V. S. Vakulyuk +3 more
doaj +1 more source
Engineering Reports, 2023 Ultrasonic impact treatment (UIT) is a new surface strengthening method to reduce the residual stresses on large pressure vessels induced by surface and repair welding. An accurate and high efficiency calculation model is the key to accurately predicting
Yun Luo, Wenchun Jiang, Qiang Zeng
doaj +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
The effect of third principal stress in the measurement of residual stresses by hole-drilling method
MATEC Web of Conferences, 2018 One of the most popular and widely used technique for measuring residual stresses is the hole-drilling method. By this method, it is possible to evaluate only biaxial residual stresses located in plane parallel to the surface, but some processes produce ...
Halabuk David, Navrat Tomas
doaj +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
The study of redistribution in residual stresses during fatigue crack growth
Journal of Mechanical Engineering and Sciences, 2021 Numerical and experimental study was conducted on fatigue crack growth (FCG) of metallic components to investigate the redistribution of mechanical residual stresses during FCG.
M. Noghabi +2 more
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