Results 61 to 70 of about 65,045 (260)

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

The study of redistribution in residual stresses during fatigue crack growth

Journal of Mechanical Engineering and Sciences, 2021
Numerical and experimental study was conducted on fatigue crack growth (FCG) of metallic components to investigate the redistribution of mechanical residual stresses during FCG.
M. Noghabi, I. Sattari-far, H. Hosseini Toudeshky   +2 more
doaj  

Drying patterns: Sensitivity to residual stresses [PDF]

Physical Review E, 2009
Volume alteration in solid materials is a common cause of material failure. Here we investigate the crack formation in thin elastic layers attached to a substrate. We show that small variations in the volume contraction and substrate restraint can produce widely different crack patterns ranging from spirals to complex hierarchical networks.
Cohen, Y., Procaccia, I., Mathiesen, Joachim   +2 more
openaire   +4 more sources

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Quantification of residual stresses in the weld by the hole-drilling method [PDF]

Metalurgija, 2008
Residual stresses arise in the structures without loading during the technological processes, e.g. casting, rolling, welding, and pressing. In the paper is described the process of quantification of residual stresses by the hole-drilling method.
Mihok, J., Pástor, M., Trebuňa, P., Šarga, P., Bocko, J., Šimčák, F., Trebuňa, F.   +6 more
doaj  

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Proposal of residual stress mitigation in nuclear safety-related austenitic stainless steel TP304 pipe bended by local induction heating process via elastic-plastic finite element analysis

Nuclear Engineering and Technology, 2019
This paper proposes a residual stress mitigation of a nuclear safety-related austenitic stainless steel TP304 pipe bended by local induction heating process via performing elastic-plastic finite element analysis. Residual stress distributions of the pipe
Jong-Sung Kim, Kyoung-Soo Kim, Young-Jin Oh, Chang-Young Oh   +3 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source