Results 181 to 190 of about 1,844,720 (244)
Mutation-Induced Resistance of SARS-CoV-2 Mpro to WU-04 Revealed by Multi-Scale Modeling. [PDF]
Int J Mol SciLiu M +8 more
europepmc +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Structural Insights into MltC from <i>Acinetobacter baumannii</i>: Conservation of the Catalytic Residue and Flexibility in Substrate Recognition. [PDF]
J Microbiol BiotechnolJang H, Kim CM, Park HH.
europepmc +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
The Role of the Electronic Structure during Protein Folding through Electron Density-Based Quantum Chemical Descriptors. [PDF]
ACS OmegaRocha-Santos A +3 more
europepmc +1 more source
Dataset of lignocellulosic residue valorization of cropland activities to produce activated carbon. [PDF]
Data BriefAmabilis-Sosa LE +6 more
europepmc +1 more source
Turn-Induction in Peptides Incorporating Novel Cyrene-Derived α,α-Disubstituted Amino Acid. [PDF]
J Pept SciBhowal KB, Hitti R, Lubell WD.
europepmc +1 more source