Results 171 to 180 of about 1,955,453 (343)

Insights into proton transfer dynamics in histidine tautomers of amyloid-β (1-40). [PDF]

Commun Chem
Tang Y, Nishimura Y, Li N, Li H, Salimi A, Ishida K, Sakti AW, Nakai H, Parida R, Lee JY.   +9 more
europepmc   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Gold(I)-Catalyzed Synthesis of 1<i>H</i>‑Isochromenes. [PDF]

ACS Omega
Mouat JM, Singh N, McCue ML, Grimm ZA, Lacker CR, Gesinski MR.   +5 more
europepmc   +1 more source

Parageobacillus thermantarcticus, an Antarctic Cell Factory: From Crop Residue Valorization by Green Chemistry to Astrobiology Studies [PDF]

, 2019
Ilaria Finore, Licia Lama, Paola Di Donato, Ida Romano, Annabella Tramice, Luigi Leone, Barbara Nicolaus, Annarita Poli   +7 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Impact of Strand Edge N-Amination on the Stability of a Parallel β-Hairpin Fold. [PDF]

J Org Chem
Starnes SK, Horne WS, Del Valle JR.
europepmc   +1 more source

Chemistry and Process Considerations for the Removal of Residues for Hybrid Bonding [PDF]

Phillip Tyler, Ian Cochran, Jonathan Fijal, John Taddei, Thomas Workman, Dominik Suwito, Guilian Gao, Gabe Guevara, G. G. Fountain, Cyprian Uzoh, Jeremy Theil, Laura Mirkarimi   +11 more
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Environmental Pollutants and Protein Destabilization in Lung Cancer: Anticancer Drug Strategies for Structural Stability. [PDF]

ACS Omega
Rasoolzadeh R, Faraji H, Baptista L, Vajedi FS, Nikoofard V, Costa LT, Carneiro JWM.   +6 more
europepmc   +1 more source