Results 221 to 230 of about 1,955,453 (343)

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

Residue-Resolved Liquid-State Hyperpolarized NMR of Peptide Condensate Surfaces. [PDF]

J Am Chem Soc
Brandis D, Turhan E, Zachrdla M, Kurzbach D.   +3 more
europepmc   +1 more source

Does mechanical screening improve fuel properties? Effects of mechanical screening of stored logging residue chips on ash chemistry and other parameters relevant for combustion [PDF]

, 2019
Marjan Bozaghian, Anna Strandberg, Teresa de la Fuente, Mikko Karjalainen, Nils Skoglund, Mikael Thyrel, Dan Bergström, Sylvia H. Larsson   +7 more
openalex  

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Fly ash upcycling to functional silica nanomaterials: insights into synthetic strategies towards efficient adsorbents for water purification. [PDF]

RSC Adv
Ruiz MS, Tunsu C, Svensson FG, Vardanyan A.   +3 more
europepmc   +1 more source

THE CHEMISTRY OF COMBINED RESIDUAL CHLORINATION

, 1982
Leao, S.F., Selleck, R.E.
openaire   +1 more source

Tratamento de resíduos de cromo gerados nas aulas de química analítica Treatment of chromium residues generated in analytical chemistry classes Tratamiento de residuos de cromo generados en las clases de química analítica

, 2019
Tamara Mayer Leite, Marlei Veiga dos Santos   +1 more
openalex   +2 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Building Trust: Validating Artificial Intelligence (AI) and Machine Learning in Agricultural Applications. [PDF]

J Agric Food Chem
Riter LS, Bienstock RJ, O'Sullivan W.
europepmc   +1 more source

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source