Results 261 to 270 of about 2,222,500 (385)

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Diverse thioether macrocyclized peptides through a radical SAM maturase. [PDF]

Proc Natl Acad Sci U S A
Eastman KAS, Roberts AG, Bandarian V.
europepmc   +1 more source

Probing the anion binding promiscuity of the soluble nitrate sensor NreA from Staphylococcus carnosus. [PDF]

Commun Chem
Ji K, Pack EK, Maydew C, Alberto KA, Abeyrathna S, Villones RLE, Gull H, Meloni G, Nielsen SO, Dodani SC.   +9 more
europepmc   +1 more source

Single‐cell transcriptomics redefines focal neuroendocrine differentiation as a distinct prostate cancer pathology

Molecular Oncology, EarlyView.
Single‐cell transcriptomics of prostate cancer patient‐derived xenografts reveals distinct features of neuroendocrine (NE) subtypes. Tumours with focal NE differentiation (NED) share transcriptional programmes with adenocarcinoma, differing from large and small cell neuroendocrine prostate cancer (NEPC). Our work defines the molecular landscape of NEPC,
Rosalia Quezada Urban, Shivakumar Keerthikumar, Ashlee Clark, Hong Wang, Belinda Phipson, Andrew Bakshi, Andrew Ryan, Heather Thorne, Renea A. Taylor, Mitchell G. Lawrence, Gail P. Risbridger, Roxanne Toivanen, David L. Goode   +12 more
wiley   +1 more source

GFAAS Determination of Antimony, Barium, and Lead Levels in Gunshot Residue Swabs: An Application in Forensic Chemistry

, 2016
Bayram Yüksel
openalex   +1 more source

Decrypting cancer's spatial code: from single cells to tissue niches

Molecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik, Shi Pan, Eloise Withnell, Hou Wang Lam, Maria Secrier   +4 more
wiley   +1 more source

Modification of the Qualitative Procedure for Lead [PDF]

, 1941
Roberts, Edwin, Roberts, L. B.
core   +2 more sources

ACS AMA: Hi, Reddit! I am Dr. Suzanne Bell, Chair of the Department of Forensic and Investigative Science at West Virginia University. Ask me anything about the chemistry of gunshot residue or educational opportunities in forensic chemistry.

, 2017
AmerChemSocietyAMA, r Science
openalex   +1 more source

Corrigendum: Computational analysis of Ayurvedic metabolites for potential treatment of drug-resistant <i>Candida auris</i>. [PDF]

Front Cell Infect Microbiol
Shah M, Zia M, Ahmad I, Khan MU, Ejaz H, Alam M, Aziz S, Nishan U, Dib H, Ullah R, Ojha SC.   +10 more
europepmc   +1 more source