Results 281 to 290 of about 2,222,500 (385)

The influence of ROS1 fusion partners and resistance mechanisms in ROS1‐TKI‐treated non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
This real‐world study of ROS1+ NSCLC highlights fusion diversity, treatment outcomes with crizotinib and lorlatinib, and in vitro experiments with resistance mechanisms. G2032R drives strong resistance to ROS1‐targeted TKIs, especially lorlatinib. Fusion partner location does not affect overall survival to crizotinib or lorlatinib. Findings support the
Fenneke Zwierenga, Christa Dijkhuizen, Patrick Korthuis, Wim Timens, Harry Groen, Jeroen Hiltermann, Anke van den Berg, Lyndsay Drayer, Anthonie van der Wekken   +8 more
wiley   +1 more source

CDK2 inhibitors: rationally directed discovery of a novel potent lead derived from cyclohepta[<i>e</i>]thieno[2,3-<i>b</i>]pyridine. [PDF]

RSC Med Chem
Ibrahim OF, Maklad RM, Abdu-Allah HHM, Syam YM, Bakhite EA.   +4 more
europepmc   +1 more source

Hypomethylating agents increase L1 retroelement expression without inducing novel insertions in myeloid malignancies

Molecular Oncology, EarlyView.
We investigated whether hypomethylating agents (HMAs) used in myeloid malignancies induce somatic retrotransposition. Our findings indicate that HMA treatment increases L1‐encoded protein expression but does not lead to detectable de novo retrotransposition events in either patient samples or cell lines.
Šárka Pavlová, Hana Svozilová, Marcela Krzyžánková, Radim Sonnek, Anastasiya Volakhava, Anastasia Smirnova, Tatiana Grigoreva, Zuzana Jašková, Hana Synáčková, Dennis Wahl, Michaela Bilčíková, Libor Červinek, Šárka Pospíšilová, Ilgar Mamedov, Karla Plevová   +14 more
wiley   +1 more source

Leveraging large language models for literature-driven prioritization of protein binding pockets. [PDF]

Bioinformatics
Stratiichuk R, Melnychenko M, Koleiev I, Voitsitskyi T, Husak V, Shevchuk N, Ostrovsky Z, Bdzhola V, Yesylevskyy S, Starosyla S, Nafiiev A.   +10 more
europepmc   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Dissipation kinetics and dietary risk assessment of metrafenone in greenhouse-grown tomatoes and cucumbers using LC-MS/MS. [PDF]

RSC Adv
Alhamami MAM, Algethami JS, Alosaimi EH, Al-Marri AH, Ramadan MF, Abdallah OI.   +5 more
europepmc   +1 more source

SensRORing cholesterol to drive protumoral myelopoiesis

Molecular Oncology, EarlyView.
Bleve et al. uncover a cholesterol‐driven immune evasion pathway, where RORγ‐dependent myelopoiesis shapes tumor immunosuppression. Targeting RORγ and PCSK9 emerges as a strategy to boost cancer immunotherapy. Protumoral myelopoiesis is a determinant of immunoevasion and tumor spread in many malignancies.
Sara Gennari, Luigi Nezi, Teresa Manzo
wiley   +1 more source

Dynamic and structural insights into allosteric regulation on MKP5 a dual-specificity phosphatase. [PDF]

Nat Commun
Skeens E, Maschietto F, Manjula R, Shillingford S, Murphy J, Lolis EJ, Batista VS, Bennett AM, Lisi GP.   +8 more
europepmc   +1 more source

The tumor–microbe connection

Molecular Oncology, EarlyView.
Tumor‐associated bacteria (TAB) dynamically influence cancer biology by modulating tumor progression, metastatic spread, and therapeutic efficacy. Their presence redefines the tumor microenvironment (TME) as a microbial–host interface, yet mechanistic insights remain limited. Understanding TAB colonization routes, functional impacts, and crosstalk with
Gerlanda Vella, Maria Rescigno
wiley   +1 more source

Structure-based design of an aromatic helical foldamer-protein interface. [PDF]

Chem Sci
Wang L, Douat C, Sigl J, Sai Reddy P, Fischer L, d'Estaintot BL, Liu Z, Pophristic V, Yang Y, Zhang Y, Huc I.   +10 more
europepmc   +1 more source