Results 111 to 120 of about 728,612 (289)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Statement on the targeted review of certain existing maximum residue levels of concern for lambda‐cyhalothrin

EFSA Journal
In compliance with Article 43 of Regulation (EC) No 396/2005, the European Food Safety Authority (EFSA) received a mandate from the European Commission to carry out a targeted review of certain existing maximum residue levels (MRLs) for lambda ...
European Food Safety Authority (EFSA)
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Residual stone fragments: systematic review of definitions, diagnostic standards

World Journal of Urology
Abstract Purpose Residual stone fragments (RSFs) remain a determining factor for evaluation of outcome an intervention for management of renal tract stones. However, there is a lack of consensus on size, location, diagnosis and management of RSF.
Çavdar, O. F., Aydin, A., Tokas, T., Tozsin, A., Gadzhiev, N., Sönmez, M. G., Tekeli, R., Ortner, G., Kallidonis, P., Akgül, B., Knoll, T., Bianchi, G., Rassweiler, J., Ahmed, K., Guven, S.   +14 more
openaire   +2 more sources

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Scientific opinion on pesticides in foods for infants and young children

EFSA Journal, 2018
Following a request from the European Commission, the EFSA Panel on Plant Protection Products and their Residues (PPR Panel) prepared a scientific opinion to provide a comprehensive evaluation of pesticide residues in foods for infants and young children.
EFSA Panel on Plant Protection Products and their Residues (PPR), Colin Ockleford, Paulien Adriaanse, Susanne Hougaard Bennekou, Philippe Berny, Theodorus Brock, Sabine Duquesne, Sandro Grilli, Antonio F. Hernandez‐Jerez, Michael Klein, Thomas Kuhl, Ryszard Laskowski, Kyriaki Machera, Olavi Pelkonen, Silvia Pieper, Robert Smith, Michael Stemmer, Ingvar Sundh, Ivana Teodorovic, Aaldrik Tiktak, Christopher J Topping, Ursula Gundert‐Remy, Mathilde Kersting, Ine Waalkens‐Berendsen, Arianna Chiusolo, Danièle Court Marques, Bruno Dujardin, Georges E N Kass, Luc Mohimont, Alexandre Nougadère, Hermine Reich, Gerrit Wolterink   +31 more
doaj   +1 more source

nexusformat/definitions: NXDL 2020.1

, 2020
Release notes: https://github.com/nexusformat/definitions/wiki/releasenotes__v2020.
Matthew D Jones, Herbert J. Bernstein, Peter Chang, Tom Schoonjans, Stuart Campbell, RussBerg, Eugen Wintersberger, Mark Koennecke, Aaron Parsons, Paul Kienzle, Ray Osborn, Freddie Akeroyd, Pete Peterson, Mark Basham, Andy Gotz, Matt Clarke, Joachim Wuttke, Pete R Jemian, Ben Watts, Tobias Richter, Timothy Spain, Aaron S. Brewster, Jacob Filik, Jan Kotanski, Michael Wharmby   +24 more
core   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source