Results 141 to 150 of about 754,687 (288)
Residue-specific conformations of the FUS CTD with ZnF folded and unfolded.
, 2019 Residue-specific values of the unfolded (blue) and folded (red) ZnF residues over 421–454 for (ΔCα–ΔCβ) (A), (ΔHα) (B), and SSP (C). (D) Sequence of the folded ZnF over residue Gln321–Gly354 with assigned NOE displayed.
Liangzhong Lim (229433) +3 more
core +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Residue-level CMM scores are noisy interface predictors.
, 2017 Left: The proportion of true contacts in the top N/10 Z(i, j) scores. Right: The top 10 contacts predicted by the residue level CMM scores for D1FJGE1_D1FJGE2, the protein complex with the highest contact ratio (0.21).
Csilla Várnai (3720010) +2 more
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
High residue farming under irrigation : strip-till [PDF]
, 2014 Strip-tillage is a low-impact cultivation technique suited to irrigated land with a lot of residue from a previous crop. A strip-till system creates both clean-till and high-residue conditions in the same field, taking advantage of both systems while ...
McGuire, Andrew
core
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
The effects of cracks on the movement of Ca+2 within gold refining residue [PDF]
, 1997 Gold refining residue is alkaline (pH> 9), saline (EC1:5: 800- 1100 mS/m) and sodic (ESP>60) (Ho et al., 1998). These chemical properties have a detrimental effect on residue physical properties (hydraulic conductivity, bulk density, porosity).
Samaraweera, S., Bell, R., Pratt, A.
core
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source