Results 121 to 130 of about 374,425 (308)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

open access: yesMolecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli   +7 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Effect of major wheat (Triticum aestivum)-based cropping system and long-term residue management practices on soil carbon and nutrient availability in bothplant and soil system in Inceptisol of sub-tropical India

open access: yesThe Indian Journal of Agricultural Sciences
Residue management has emerged as a critical agronomic strategy for enhancing crop productivity while reducing the environmental footprint of agricultural practices.
DEWALI ROY, TAPAN JYOTI PURAKAYASTHA
doaj   +1 more source

Example of an iterative approach conducted with smallholders in Northern Laos for the adoption of direct seeding mulch-based cropping systems [PDF]

open access: yes, 2005
Since the 1990s, in the southern districts of Xayabury province in the Mekong corridor, traditional farming systems have changed through extensive agricultural development based on cash-crop production.
Chantharath, Bounsay   +6 more
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Organic residues - a resource for arable soils [PDF]

open access: yes, 2005
An increased recirculation of urban organic residues to arable soils has several environmental benefits, but there is a need for reliable test systems to ensure that soil quality is maintained.
Odlare, Monica
core  

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