Results 181 to 190 of about 1,104,642 (331)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Beyond contacts: The important role of the support region in protein complex assembly. [PDF]

Protein Sci
Miclot T, Timr S.
europepmc   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

The effect of ionic strength on PETase enzymes: An experimental and computational study. [PDF]

Protein Sci
Berselli A, Carletti A, Menziani MC, Bhattacharya S, Castagna R, Parisini E, di Rocco G, Muniz-Miranda F.   +7 more
europepmc   +1 more source

The method of correcting codes formation in the residue number system [PDF]

, 2016
Derkach, R. V., Tsavolyk, T. G., Yatskiv, N. G., Деркач, Р. В., Цаволик, Т. Г., Яцків, Н. Г.   +5 more
core  

A New Cryptographic Model based on Residue Number System and Ribonucleic Acid Properties

, 2020
Abolore Muhamin, Kolawole Bariu, Kazeem Alagbe   +2 more
openalex   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Optimizing Livelihood and Environmental Benefits from Crop Residues in Smallholder Crop-Livestock Systems in Southern Africa. Series Paper Number 11 [PDF]

, 2013
Sabine Homann, E. Bandason, F. Maute, D. Nkomboni, Nkululeko Mpofu, Jonathan Tanganyika, André van Rooyen, Timothy Gondwe, P. F. Dias, S. Ncube, Sibusiso Moyo, Sheryl Hendricks, Fantu Nisrane   +12 more
openalex  

Efficient Implementation of NTRU Cryptography using Residue Number System

, 2015
Azin Zalekian, Mohammad Esmaeildoust, Amer Kaabi   +2 more
openalex   +1 more source