Results 61 to 70 of about 425,450 (331)

Asymptotic enumeration of correlation-immune boolean functions [PDF]

open access: yes, 2009
A boolean function of $n$ boolean variables is {correlation-immune} of order $k$ if the function value is uncorrelated with the values of any $k$ of the arguments. Such functions are of considerable interest due to their cryptographic properties, and are
Canfield, E. Rodney   +4 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The Recalcitrance and Resilience of Scientific Function

open access: yesPoroi, 2020
"Function" is a vitally important concept in the scientific community. Scientists use it to describe and address a wide variety of research problems. In publications, however, scientists within and across disciplines interpret function differently. For example, intense debate surrounds what percentage of the human genome should be deemed "functional ...
Keeling, Diane Marie   +3 more
openaire   +2 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

An MBSE Approach for Development of Resilient Automated Automotive Systems

open access: yesSystems, 2019
Advanced driver assistance and automated driving systems must operate in complex environments and make safety-critical decisions. Resilient behavior of these systems in their targeted operation design domain is essential.
Joseph D’Ambrosio   +6 more
doaj   +1 more source

Relationships between Psychosocial Resilience and Physical Health Status of Western Australian Urban Aboriginal Youth. [PDF]

open access: yesPLoS ONE, 2015
BACKGROUND:Psychosocial processes are implicated as mediators of racial/ethnic health disparities via dysregulation of physiological responses to stress. Our aim was to investigate the extent to which factors previously documented as buffering the impact
Katrina D Hopkins   +3 more
doaj   +1 more source

Strain induced magnetic domain evolution and spin re-orientation transition in epitaxial manganite films

open access: yes, 2012
The evolution of magnetic domain structure in epitaxial La$_{0.625}$Ca$_{0.375}$MnO$_3$ films on (001) NdGaO$_3$ is monitored as a function of temperature and magnetic field using Magnetic Force Microscopy.
Budhani, R. C.   +3 more
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

Home - About - Disclaimer - Privacy