Results 51 to 60 of about 895,380 (269)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Process for preparing polyimide adhesives [PDF]

, 1975
High bonding strengths are obtained for metals and fiber-reinforced organic resin composites with no significant loss in thermo-oxidative stability of the adhesive ...
Bell, V. L., Progar, D. J., St. Clair, T. L.   +2 more
core   +1 more source

Investigation of the effect of double-walled carbon nanotubes on the curing reaction kinetics and shear flow of an epoxy resin [PDF]

, 2012
In this article, the effect of combined temperature-concentration and shear rate conditions on the rheology of double-walled carbon nanotubes (DWCNTs)/RTM6-Epoxy suspension was investigated to determine the optimum processing conditions.
Abdalla, Aduriz, Barrau, Battisti, Bauhöfer, Carreau, Deng, Dijkstra, Dutta, Eken, Eyring, Flahaut, Flahaut, Fulcher, Gojny, Gong, Gonzalez-Romero, Gupta, Han, Hobbie, Hough, Karkanas, Kazilas, Kim, Kim, Kovacs, Lee, Ma, Moniruzzaman, Nielsen, Park, Pascault, Puglia, Qiu, Qiu, Song, Sourour, Suave, Sui, Tammann, Tao, Terekhina, Terenzi, Torre, Veedu, Vogel, Wang, Williams, Xie, Yasuda, Zhou, Zhu, Špitalský   +52 more
core   +3 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Water absorption and curing time performance of urea formaldehyde resin mixed with different amount phosphorous-based fire retardants. [PDF]

, 2008
The curing time and the properties of urea formaldehyde (UF) resin mixed with fire retardants, BP (mixture of boric acid, guanylurea phosphate and phosphoric acid), monoammonium phosphate (MAP) and diammonium phosphate (DAP) were studied. There were two
Abdul Malek, Abdul Rashid, Abood, Faizah, Ashaari, Zaidon, Kamal, Izran, Misran, Suffian, Rusli, Rafeadah, Saad, Mohamad Jani, Thirmizir, Mohd Zharif   +7 more
core  

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Gecko's Toes‐Inspired High‐Adhesive and Self‐Healable Elastomer in Marine Conditions: Humidity‐Triggered Crosslinking and Damage Sensing

SmartMat
The development of smart materials capable of underwater self‐healing, mechanical robustness and damage‐healing sensing attributes holds great promise for applications in marine energy exploitation.
Sihan Gu, Dezhi Jiao, Li Cheng, Enkang Wu, Zhengsen Wang, Lanyue Cui, Chengbao Liu   +6 more
doaj   +1 more source

Effects of resins on mechanical performance of polymer concrete

Građevinar, 2021
Cement manufacturing is currently responsible for one of the highest levels of carbon dioxide (CO2) emissions and energy consumption in construction industry.
Ferit Cakir, Armin Karimi, Arif Ulu, Mustafa Gundogdu   +3 more
doaj   +1 more source

A comparison of ion-exchange resins and activated carbon in recovering gold from cyanide leach solutions with low levels of copper

Bulletin of the Mineral Research and Exploration, 2022
This study was conducted to determine the effectiveness of three different adsorbents for the adsorption of gold from a real cyanide leach liquor. An activated carbon (NORIT GAC 1240), strong base (Purogold A194), and weak base (Purogold S992) resins ...
Deus Albert Msumange, Ersin Yener Yazıcı, Oktay Celep, Hacı Deveci   +3 more
doaj   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source