Results 141 to 150 of about 1,885,146 (393)
Investigation of bedrock depths by electrical-resistivity methods in the Ripon-Fond du Lac area, Wisconsin [PDF]
, 1950 H. Cecil Spicer
openalex +1 more source
Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Molecular Oncology, EarlyView.Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley +1 more source
JAK inhibitors to treat STAT3 gain-of-function: a single-center report and literature review
Frontiers in ImmunologyObjectiveThe signal transducer and activator of transcription 3 (STAT3) gain-of-function (GOF) syndrome (STAT3-GOF) is an inborn error of immunity (IEI) characterized by diverse manifestations of immune dysregulation that necessitate systemic ...
Faranaz Atschekzei +20 more
doaj +1 more source
On the construction of artillery and other vessels to resist great internal pressure [PDF]
J A LONGRIDGE
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One-step air bridge fabrication technique using 3D e-beam lithography [PDF]
, 2013 A new technique is demonstrated for the realisation of air bridges using one lithographic step. Gray scale lithography is used for the formation of 3D profiles on polymethyl methacrylate (PMMA) where a variable dose exposure is applied to create a ...
Cumming, David R.S. +2 more
core
Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence
Molecular Oncology, EarlyView.The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova +18 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma +9 more
wiley +1 more source