Results 231 to 240 of about 1,998,168 (383)

Exploring Adults' Experiences with Tirzepatide for Weight Loss: A Mixed-Methods Study. [PDF]

open access: yesHealthcare (Basel)
Adam S   +5 more
europepmc   +1 more source

Resistive Training and Molecular Regulators of Vascular-Metabolic Risk in Chronic Stroke

open access: green, 2016
Alice S. Ryan   +3 more
openalex   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung   +17 more
wiley   +1 more source

Mice lacking ghrelin receptors resist the development of diet-induced obesity.

open access: yesJournal of Clinical Investigation, 2005
J. Zigman   +14 more
semanticscholar   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Stress decreases the ability to resist smoking and potentiates smoking intensity and reward

open access: yesJournal of Psychopharmacology, 2011
S. McKee   +6 more
semanticscholar   +1 more source

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