Results 121 to 130 of about 3,014,748 (294)

Gold-cobalt resistance alloys

, 1935
J.L. Thomas
openalex   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Assessing the utility of genomic selection to breed for durable Ascochyta blight resistance in chickpea. [PDF]

Plant Genome
Lin Z, Li Y, Riaz A, Sudheesh S, Yazdifar S, Atieno J, Blake S, Croser J, Fanning J, Hayden MJ, Kaur S.   +10 more
europepmc   +1 more source

Changes in Isoniazid Resistance of Tubercle Bacilli after Cessation of Treatment: Report by the Laboratory Subcommittee of the Tuberculosis Chemotherapy Trials Committee, Medical Research Council M.R.C. ISONIAZID TRIAL: REPORT NO. 6 [PDF]

, 1954

openalex   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

Overexpression of the GmERF071 gene confers resistance to soybean cyst nematode in soybean. [PDF]

Plant Genome
Xiong E, Xu J, Feng P, Lian Y, Zhi X, Li K, Zhang E, Li B, Zhao S, Liu C, Wei C, Li P, Zhao Y, Zhao L, Zheng M, Zhang H, Li Y, Chu S, Jiao Y.   +18 more
europepmc   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

A five-year examination into the occurrence of herbicide-resistant barnyardgrass populations in paddy from Jiangsu Province, China. [PDF]

Sci Rep
Hu X, Xu Y, Li C, Mao H, Liu Z, Xiao Y, Li Y, Yang X.   +7 more
europepmc   +1 more source

Corrosion Resistance of High-Strength Low-Alloy Steels as Influenced by Composition and Environment

, 1954
C. P. Larrabee
openalex   +2 more sources