Results 51 to 60 of about 8,162,878 (359)

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

A framework for identifying the recent origins of mobile antibiotic resistance genes

Communications Biology, 2021
Ebmeyer and colleagues developed a genomic framework for identification and scrutiny of the origins of antibiotic resistance genes. Using data scoured from the literature and publicly available genomes, their results indicate that only 81% of previously ...
Stefan Ebmeyer, Erik Kristiansson, D. G. Joakim Larsson   +2 more
doaj   +1 more source

Genomic introgression mapping of field-derived multiple-anthelmintic resistance in Teladorsagia circumcincta [PDF]

, 2017
Preventive chemotherapy has long been practiced against nematode parasites of livestock, leading to widespread drug resistance, and is increasingly being adopted for eradication of human parasitic nematodes even though it is similarly likely to lead to ...
Bisset, Stewart A, Choi, Young-Jun, Doyle, Stephen R, Grant, Warwick N, Hallsworth-Pepin, Kymberlie, Martin, John, Mitreva, Makedonka   +6 more
core   +3 more sources

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

Why make it if you can take it: review on extracellular cholesterol uptake and its importance in breast and ovarian cancers

Journal of Experimental & Clinical Cancer Research
Cholesterol homeostasis is essential for healthy mammalian cells and dysregulation of cholesterol metabolism contributes to the pathogenesis of various diseases including cancer. Cancer cells are dependent on cholesterol.
Anna Røssberg Lauridsen, Aikaterini Skorda, Nuggi Ingholt Winther, Marie Lund Bay, Tuula Kallunki   +4 more
doaj   +1 more source

Integrating whole-genome sequencing within the National Antimicrobial Resistance Surveillance Program in the Philippines

Nature Communications, 2020
Whole-genome sequencing (WGS) can support drug resistance surveillance, but is rare in low- and middle-income countries. Here, the authors integrate WGS within the national antimicrobial resistance surveillance program in the Philippines and conduct a ...
Silvia Argimón, Melissa A. L. Masim, June M. Gayeta, Marietta L. Lagrada, Polle K. V. Macaranas, Victoria Cohen, Marilyn T. Limas, Holly O. Espiritu, Janziel C. Palarca, Jeremiah Chilam, Manuel C. Jamoralin, Alfred S. Villamin, Janice B. Borlasa, Agnettah M. Olorosa, Lara F. T. Hernandez, Karis D. Boehme, Benjamin Jeffrey, Khalil Abudahab, Charmian M. Hufano, Sonia B. Sia, John Stelling, Matthew T. G. Holden, David M. Aanensen, Celia C. Carlos   +23 more
doaj   +1 more source

Dietary Fibre Supplementation Improves Semen Production by Increasing Leydig Cells and Testosterone Synthesis in a Growing Boar Model

Frontiers in Veterinary Science, 2022
Testicular development is imperative to spermatogenesis, and pre-puberty is the key period for testis development. This study, therefore, investigated the effects of fibre supplementation on testis development and its possible mechanism in a growing boar
Yan Lin, Yan Lin, De Wu, De Wu, Lianqiang Che, Lianqiang Che, Zhengfeng Fang, Zhengfeng Fang, Shengyu Xu, Shengyu Xu, Bin Feng, Bin Feng, Yong Zhuo, Yong Zhuo, Jian Li, Jian Li, Caimei Wu, Caimei Wu, Junjie Zhang, Lujie Li, Lujie Li   +20 more
doaj   +1 more source

Resistance Monitoring [PDF]

, 2002
The problem considered was that of estimating the temperature field in a contaminated region of soil, using measurements of electrical potential and current and also of temperature, at accessible points such as the wells and electrodes and the soil ...
Bohun, Sean C., Westbrook, Rex
core  

Understanding cisplatin resistance using cellular models [PDF]

, 2007
Many mechanisms of cisplatin resistance have been proposed from studies of cellular models of resistance including changes in cellular drug accumulation, detoxification of the drug, inhibition of apoptosis and repair of the DNA adducts.
Davey, Mary W., Stordal, Britta
core   +2 more sources

Resistance and cross‐resistance to abacavir [PDF]

HIV Medicine, 2001
Background Abacavir (ABC) is a potent nucleoside reverse transcriptase inhibitor (NRTI) used in multi‐drug antiretroviral regimens and in combination with other NRTIs, protease and/or non‐nucleoside reverse transcriptase inhibitors (NNRTIs) in both treatment naive and treatment experienced patients.Patterns of resistance Resistance to ABC has been ...
openaire   +2 more sources