Results 71 to 80 of about 5,285,484 (304)

Modified genome comparison method: a new approach for identification of specific targets in molecular diagnostic tests using Mycobacterium tuberculosis complex as an example

BMC Infectious Diseases, 2018
Background The first step of designing any genome-based molecular diagnostic test is to find a specific target sequence. The modified genome comparison method is one of the easiest and most comprehensive ways to achieve this goal. In this study, we aimed
Alireza Neshani, Reza Kamali Kakhki, Mojtaba Sankian, Hosna Zare, Amin Hooshyar Chichaklu, Mahsa Sayyadi, Kiarash Ghazvini   +6 more
doaj   +1 more source

Resistant Hypertension or Resistant Prescribing? [PDF]

Hypertension, 2011
See related article, pp 1008–1013 The term “resistant hypertension” (RH) evokes a myriad of clinical descriptions, nearly all of which implicitly ascribe origins of the problem to characteristics inherent within the patient or maleficent qualities of the disease itself.
openaire   +2 more sources

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Antibiotic resistance in European wastewater treatment plants mirrors the pattern of clinical antibiotic resistance prevalence [PDF]

, 2019
Integrated antibiotic resistance (AR) surveillance is one of the objectives of the World Health Organization global action plan on antimicrobial resistance. Urban wastewater treatment plants (UWTPs) are among the most import- ant receptors and sources
Narciso-da-Rocha, Carlos, Stedtfeld, Robert D., Sorum, Henning, Vaz-Moreira, Ivone, O_Sullivan, Kristin, Walsh, Fiona, Do, Thi Thuy, Cacace, Damlano, Henriques, Isabel, Sheng, Hongjie, Giustina, Saulo Varela Della, Virta, Marko, Pärnänen, Katariina M. M., Elpers, Christian, O’Sullivan, Kristin, Thuy Do, Thi, Luis Martinez, Jose, Martinez, Jose Luis, O'Sullivan, Kristin, Karkman, Antti, Michael, Stella G, Fatta-Kassinos, Despo, Sørum, Henning, Kneis, David, Jaeger, Thomas, Rodriguez-Mozaz, Sara, Berendonk, Thomas U., Cacace, Damiano, Michael, Stella G., Manaia, Célia M., Parnanen, Katariina MM, Tiedje, James M., Varela Della Giustina, Saulo, Michael-Kordatou, Irene, Schwartz, Thomas   +34 more
core   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Resistance and cross‐resistance to abacavir [PDF]

HIV Medicine, 2001
Background Abacavir (ABC) is a potent nucleoside reverse transcriptase inhibitor (NRTI) used in multi‐drug antiretroviral regimens and in combination with other NRTIs, protease and/or non‐nucleoside reverse transcriptase inhibitors (NNRTIs) in both treatment naive and treatment experienced patients.Patterns of resistance Resistance to ABC has been ...
openaire   +2 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Biofilm-driven LPS remodeling and colanic acid overproduction mediate biocide adaptation and antibiotic cross-resistance in E. coli

npj Antimicrobials and Resistance
The identification of the determinants driving antimicrobial resistance is a prerequisite for improving the control of resistance emergence and dissemination.
Raphaël Charron, Pierre Lemée, Thibaut Léger, Léonie Pigeon, Marine Boulanger, Paméla Houée, Julien Deschamps, Antoine Huguet, Christophe Soumet, Romain Briandet, Arnaud Bridier   +10 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

resistance

, 2011
data file for analysis of resistance (= proportion infected individuals); text file with column headers; further details see Materials and methods in the ...
Oliver Kaltz (122934), Alison B Duncan (3262779), Simon Fellous (122925)   +2 more
core   +1 more source