Results 91 to 100 of about 5,285,484 (304)

Staphylococcus aureus ST764-SCCmecII high-risk clone in bloodstream infections revealed through national genomic surveillance integrating clinical data

Nature Communications
Antimicrobial resistance is a global health concern, and methicillin-resistant Staphylococcus aureus (MRSA) is one of the highest-priority organisms exhibiting this phenotype.
Junzo Hisatsune, Shoko Kutsuno, Yasuhisa Iwao, Kasumi Ishida-Kuroki, Koji Yahara, Norikazu Kitamura, Toshiki Kajihara, Shizuo Kayama, Yo Sugawara, Hiroki Kitagawa, Hiroki Ohge, Tomoyuki Mizukami, JARBS-SA Consortium, Takeshi Takahashi, Fumio Kawano, Motoyuki Sugai   +15 more
doaj   +1 more source

Dealing with indeterminate outcomes in antimalarial drug efficacy trials: a comparison between complete case analysis, multiple imputation and inverse probability weighting

BMC Medical Research Methodology, 2019
Background Antimalarial clinical efficacy studies for uncomplicated Plasmodium falciparum malaria frequently encounter situations in which molecular genotyping is unable to discriminate between parasitic recurrence, either new infection or recrudescence.
Prabin Dahal, Kasia Stepniewska, Philippe J. Guerin, Umberto D’Alessandro, Ric N. Price, Julie A. Simpson   +5 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Youth as change makers on antimicrobial resistance: an evidence-based call-to-action

Nature Communications
Youth represent un-tapped potential within the fight against antimicrobial resistance (AMR). This commentary describes the co-creation process of the Youth Manifesto on AMR which seeks to generate consensus on how equitable engagement of youth can be ...
Jessica Mitchell, Salman, F. Khan, Cristina Almazidou, Augusto Barón-Cruz, Randa A. Bazzi, Pablo Estrella-Porter, Nahashon, K. Gicheru, Karina Khatic, Michael, J. Mosha, Marina Ungurenci, Boama. E. P. Noali, Kalai Wong, Francesca Zanni   +12 more
doaj   +1 more source

Sewage effluent from an Indian hospital harbors novel carbapenemases and integron-borne antibiotic resistance genes

Microbiome, 2019
Background Hospital wastewaters contain fecal material from a large number of individuals, of which many are undergoing antibiotic therapy. It is, thus, plausible that hospital wastewaters could provide opportunities to find novel carbapenemases and ...
Nachiket P. Marathe, Fanny Berglund, Mohammad Razavi, Chandan Pal, Johannes Dröge, Sharvari Samant, Erik Kristiansson, D. G. Joakim Larsson   +7 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Resistance of a compartmented surface-effect ship [PDF]

, 2010
A series of carefully controlled experiments on the resistance of a model of a compartmented surface-effect ship has been conducted in a towing tank. Configurations of the model included cases encompassing one subcushion and two subcushions, as well as ...
Day, Alexander, Clelland, David, Beveridge, Philip, Doctors, Lawrence   +3 more
core   +3 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

4th ASM Conference on Antimicrobial Resistance in Zoonotic Bacteria and Foodborne Pathogens, 08 May 2015 - 11 May 2015, Washington, DC : Final Program and Abstracts

, 2015
The 4th ASM Conference on Antimicrobial Resistance in Zoonotic Bacteria and Foodborne Pathogens will continue and expand the excellent existing scientific agenda to include emphases on novel approaches to molecular typing, whole genome sequencing and its

core  

Early Gut Microbiota Intervention Suppresses DSS-Induced Inflammatory Responses by Deactivating TLR/NLR Signalling in Pigs

Scientific Reports, 2017
Recent metagenomic studies suggest that innate and adaptive immune phenotypes can be programmed via gut microbiota-host interactions mediated via activation of pattern recognition receptors (PRRs) on host cells.
Yi Xiao, Honglin Yan, Hui Diao, Bing Yu, Jun He, Jie Yu, Ping Zheng, Xiangbing Mao, Yuheng Luo, Daiwen Chen   +9 more
doaj   +1 more source