Results 91 to 100 of about 3,968,554 (331)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Genomic selection on cacao for disease resistance : S04T08 [PDF]

, 2013
Under favorable conditions, diseases can cause losses up to 100% in cacao. Breeding has been the most effective strategy in reducing these losses. However, breeding is limited by the: a) long generation time; b) large tree size (9 m2/tree); c) multiple ...
Clément, Didier, Gramacho, Karina Peres, Lanaud, Claire, Lopes, Uilson Vanderlei, Monteiro, Wilson Reis, Phillips-Mora, Wilbert, Pires, José Luis   +6 more
core  

Drought Resistance in Rice from Conventional to Molecular Breeding: A Review

International Journal of Molecular Sciences, 2019
Drought is the leading threat to agricultural food production, especially in the cultivation of rice, a semi-aquatic plant. Drought tolerance is a complex quantitative trait with a complicated phenotype that affects different developmental stages in ...
Y. Oladosu, M. Rafii, Chukwu Samuel, A. Fatai, U. Magaji, I. Kareem, Zarifth Shafika Kamarudin, Ismaila Muhammad, K. Kolapo   +8 more
semanticscholar   +1 more source

Genome-assisted Breeding For Drought Resistance [PDF]

Current Genomics, 2016
Drought stress caused by unpredictable precipitation poses a major threat to food production worldwide, and its impact is only expected to increase with the further onset of climate change. Understanding the effect of drought stress on crops and plants' response is critical for developing improved varieties with stable high yield to fill a growing food
Khan, A., Sovero, V., Gemenet, D.
openaire   +2 more sources

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

OsSCYL2 is Involved in Regulating ABA Signaling-Mediated Seed Germination in Rice

Plants
Seed germination represents a multifaceted biological process influenced by various intrinsic and extrinsic factors. In the present study, our investigation unveiled the regulatory role of OsSCYL2, a gene identified as a facilitator of seed germination ...
Minyan Xu, Wei Zhang, Yuhuan Jiao, Qing Yang, Meng Chen, Hu Cheng, Beijiu Cheng, Xin Zhang   +7 more
doaj   +1 more source

Vermont On-Farm Spring Wheat Breeding Trials [PDF]

, 2013
On-farm wheat breeding began in Vermont, in cooperation with UVM Extension, in 2007 with a USDA SARE grant to build farmer knowledge in plant breeding.
Burke, Conner, Cummings, Erica, Darby, Heather, Harwood, Hannah, Monahan, Susan   +4 more
core   +1 more source

Selection and validation of potato candidate genes for maturity corrected resistance to Phytophthora infestans based on differential expression combined with SNP association and linkage mapping. [PDF]

, 2015
Late blight of potato (Solanum tuberosum L.) caused by the oomycete Phytophthora infestans (Mont.) de Bary, is one of the most important bottlenecks of potato production worldwide.
Gebhardt, C., Lubeck, J., Muktar, M., Strahwald, J.   +3 more
core   +3 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

The complex transcriptional regulation of heat stress response in maize

Stress Biology
As one of the most important food and feed crops worldwide, maize suffers much more tremendous damages under heat stress compared to other plants, which seriously inhibits plant growth and reduces productivity.
Mingxiu Ruan, Heng Zhao, Yujing Wen, Hao Chen, Feng He, Xingbo Hou, Xiaoqin Song, Haiyang Jiang, Yong-Ling Ruan, Leiming Wu   +9 more
doaj   +1 more source