Results 111 to 120 of about 3,968,554 (331)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Selection for resistance to cacao Moniliasis assisted by molecular markers : S04P06 [PDF]

, 2013
The basidiomycete Moniliophthora rorer, the etiological agent of Moniliasis, reaches cacao plantations (Theobroma cacao) in Central and South Americas, but its occurrence is still not registered in Brazil .
Clément, Didier, Gramacho, Karina Peres, Lopes, Uilson Vanderlei, Reis, M.R.A.   +3 more
core  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Evolutionary plant breeding for low input systems [PDF]

, 2005
Heritable variation is at the heart of the process of evolution. However, variation is restricted in breeding for uniform crop populations using the pedigree line approach. Pedigree lines are successful in agriculture because synthetic inputs are used to
Phillips, Scott, Wolfe, Martin
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

The ZmHSF08-ZmUGT92A1 module regulates heat tolerance by altering reactive oxygen species levels in maize

Crop Journal
GTs (Glycosyltransferases) are important in plant growth and abiotic stresses. However, its role in maize heat response is far from clear. Here, we describe the constitutively expressed UDP-glycosyltransferase ZmUGT92A1, which has a highly conserved PSPG
Hao Li, Jing Wang, Menglong Li, Leiming Wu, Wenhui Rao, Xiaojian Peng, Haiyang Jiang   +6 more
doaj   +1 more source

Societal Costs of Late Blight in Potato and Prospects of Durable Resistance Through Cisgenic Modification [PDF]

, 2008
In the European Union almost 6 Mha of potatoes are grown representing a value of close to ¿6,000,000,000. Late blight caused by Phytophthora infestans causes annual losses (costs of control and damage) estimated at more than ¿1,000,000,000.
Boonekamp, P.M., Haverkort, A.J., Hutten, R.C.B., Jacobsen, E., Kessel, G.J.T., Lotz, L.A.P., Visser, R.G.F., Vossen, E.A.G., van der   +7 more
core   +2 more sources

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

The Mitochondrial Protein RESISTANCE to APHIDS 9 Interacts with S40 to Resist Aphid Infestation by Modulating Reactive Oxygen Species Homeostasis in Maize (Zea mays)

Advanced Science
As the corn aphid (Rhopalosiphum maidis) poses a major threat to maize (Zea mays) growth, there is much interest in identifying aphid resistance genes. In this study, an aphid‐susceptible maize mutant from an ethyl methanesulfonate–mutagenized library is
Chuanhong Wang, Xinqiao Zhang, Zhen Tao, Lei Wang, Shijie Huang, Tengyue Wang, Yibing Zhao, Jinghui Dong, Jing Ma, Chang Chang, Xingzhi Chen, Ning Lin, Peijin Li   +12 more
doaj   +1 more source

Evaluation and Mapping of a Leaf Rust Resistance Gene Derived from Hordeum vulgare subsp. spontaneum

Czech Journal of Genetics and Plant Breeding, 2004
Studies of marker development were performed on a doubled haploid population derived from the cross of a highly resistant line H. spontaneum 677 × Krona (susceptible).
Doris Kopahnke, Marion Nachtigal, Frank Ordon, Brian J. Steffenson   +3 more
doaj   +1 more source